SCOPe 2.04: Domain d4pp9b_: 4pp9 B:

Lineage for d4pp9b_ (4pp9 B:)

1. Root: SCOPe 2.04

2. Class d: Alpha and beta proteins (a+b) [53931] (380 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Tyrosine-protein kinase Itk/Tsk [111194] (1 species)
   PTK group; Tec/Atk subfamily; non-membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [111195] (28 PDB entries)
   Uniprot Q08881 357-619

8. Domain d4pp9b_: 4pp9 B: [257521]
   automated match to d4kioc_
   complexed with 2vt, so4

Details for d4pp9b_

PDB Entry: 4pp9, 2.58 Å

PDB Description: itk kinase domain with compound 1 (n-[1-(3-cyanobenzyl)-1h-pyrazol-4- yl]-2h-indazole-3-carboxamide)

PDB Compounds: (B:) Tyrosine-protein kinase ITK/TSK

SCOPe Domain Sequences for d4pp9b_:

Sequence, based on SEQRES records:

>d4pp9b_ d.144.1.7 (B:) Tyrosine-protein kinase Itk/Tsk {Human (Homo sapiens) [TaxId: 9606]}
svidpseltfvqeigsgqfglvhlgywlnkdkvaiktiregamseedfieeaevmmklsh
pklvqlygvcleqapiclvfefmehgclsdylrtqrglfaaetllgmcldvcegmaylee
acvihrdlaarnclvgenqvikvsdfgmtrfvlddqetsstgtkfpvkwaspevfsfsry
ssksdvwsfgvlmwevfsegkipyenrsnsevvedistgfrlykprlasthvyqimnhcw
kerpedrpafsrllrqlaeiaesg

Sequence, based on observed residues (ATOM records):

>d4pp9b_ d.144.1.7 (B:) Tyrosine-protein kinase Itk/Tsk {Human (Homo sapiens) [TaxId: 9606]}
svidpseltfvqeigsgqfglvhlgywlnkdkvaiktiregamseedfieeaevmmklsh
pklvqlygvcleqapiclvfefmehgclsdylrtqrglfaaetllgmcldvcegmaylee
acvihrdlaarnclvgenqvikvsdfgmpvkwaspevfsfsryssksdvwsfgvlmwevf
segkipyenrsnsevvedistgfrlykprlasthvyqimnhcwkerpedrpafsrllrql
aeiaesg

Timeline for d4pp9b_:

• d4pp9b_ is new in SCOPe 2.04-stable
  
• d4pp9b_ appears in SCOPe 2.05
  
• d4pp9b_ appears in the current release, SCOPe 2.08, called d4pp9b1