SCOPe 2.05: Domain d4ks6a_: 4ks6 A:

Lineage for d4ks6a_ (4ks6 A:)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.92: Zincin-like [55485] (2 superfamilies)
   contains mixed beta sheet with connection over free side of the sheet

4. Superfamily d.92.1: Metalloproteases ("zincins"), catalytic domain [55486] (18 families)

5. Family d.92.1.7: Clostridium neurotoxins, catalytic domain [55512] (2 proteins)

6. Protein Botulinum neurotoxin [55513] (4 species)

7. Species Clostridium botulinum, serotype A [TaxId:1491] [55514] (26 PDB entries)
   Uniprot P10845 1-419

8. Domain d4ks6a_: 4ks6 A: [256895]
   automated match to d4ej5a_
   complexed with edo, gol, peg, pgo, so4, zn; mutant

Details for d4ks6a_

PDB Entry: 4ks6, 1.93 Å

PDB Description: crystal structure of the catalytic domain of botulinum neurotoxin bont/a c134s mutant with covalent inhibitor that modifies cys-165 causing disorder in 166-174 stretch

PDB Compounds: (A:) Botulinum neurotoxin A light chain

SCOPe Domain Sequences for d4ks6a_:

Sequence; same for both SEQRES and ATOM records:

>d4ks6a_ d.92.1.7 (A:) Botulinum neurotoxin {Clostridium botulinum, serotype A [TaxId: 1491]}
gshmpfvnkqfnykdpvngvdiayikipnagqmqpvkafkihnkiwviperdtftnpeeg
dlnpppeakqvpvsyydstylstdnekdnylkgvtklferiystdlgrmlltsivrgipf
wggstidtelkvidtnsinviqpdgsyrseelnlviigpsadiiqfecksfghevlnltr
ngygstqyirfspdftfgfeeslevdtnpllgagkfatdpavtlahelihaghrlygiai
npnrvfkvntnayyemsglevsfeelrtfgghdakfidslqenefrlyyynkfkdiastl
nkaksivgttaslqymknvfkekyllsedtsgkfsvdklkfdklykmlteiytednfvkf
fkvlnrktylnfdkavfkinivpkvnytiydgfnlrntnlaanfngqnteinnmnftklk
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Timeline for d4ks6a_:

• d4ks6a_ first appeared in SCOPe 2.04
  
• d4ks6a_ is called d4ks6a1 in SCOPe 2.06
  
• d4ks6a_ appears in the current release, SCOPe 2.08, called d4ks6a1