SCOPe 2.06: Domain d4j6ia1: 4j6i A:144-321

Lineage for d4j6ia1 (4j6i A:144-321)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.15: beta-Grasp (ubiquitin-like) [54235] (14 superfamilies)
   core: beta(2)-alpha-beta(2); mixed beta-sheet 2143

4. Superfamily d.15.1: Ubiquitin-like [54236] (11 families)

5. Family d.15.1.0: automated matches [191343] (1 protein)
   not a true family

6. Protein automated matches [190233] (22 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187090] (78 PDB entries)

8. Domain d4j6ia1: 4j6i A:144-321 [252815]
   Other proteins in same PDB: d4j6ia2, d4j6ia3, d4j6ia4, d4j6ia5
   automated match to d1e7ua3
   complexed with 1jv

Details for d4j6ia1

PDB Entry: 4j6i, 2.9 Å

PDB Description: Discovery of thiazolobenzoxepin PI3-kinase inhibitors that spare the PI3-kinase beta isoform

PDB Compounds: (A:) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

SCOPe Domain Sequences for d4j6ia1:

Sequence, based on SEQRES records:

>d4j6ia1 d.15.1.0 (A:144-321) automated matches {Human (Homo sapiens) [TaxId: 9606]}
seesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwvt
skplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkmakkkslmdipe
sqseqdfvlrvcgrdeylvgetpiknfqwvrhclkngeeihvvldtppdpaldevrke

Sequence, based on observed residues (ATOM records):

>d4j6ia1 d.15.1.0 (A:144-321) automated matches {Human (Homo sapiens) [TaxId: 9606]}
seesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwvt
skplpeylwkkianncifivihrsttsqtikvspddtpgailqsffteqdfvlrvcgrde
ylvgetpiknfqwvrhclkngeeihvvldtppdpaldevrke

Timeline for d4j6ia1:

• d4j6ia1 first appeared in SCOPe 2.04
  
• d4j6ia1 appears in SCOPe 2.05
  
• d4j6ia1 appears in SCOPe 2.07
  
• d4j6ia1 appears in the current release, SCOPe 2.08