SCOPe 2.05: Domain d4hlea4: 4hle A:726-1092

Lineage for d4hlea4 (4hle A:726-1092)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (21 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (615 PDB entries)

8. Domain d4hlea4: 4hle A:726-1092 [252466]
   Other proteins in same PDB: d4hlea1, d4hlea2, d4hlea3
   automated match to d1e7ua4
   complexed with 17v

Details for d4hlea4

PDB Entry: 4hle, 2.78 Å

PDB Description: Compound 21 (1-alkyl-substituted 1,2,4-triazoles)

PDB Compounds: (A:) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

SCOPe Domain Sequences for d4hlea4:

Sequence, based on SEQRES records:

>d4hlea4 d.144.1.0 (A:726-1092) automated matches {Human (Homo sapiens) [TaxId: 9606]}
tamlhdftqqvqviemlqkvtldikslsaekydvssqvisqlkqklenlqnsqlpesfrv
pydpglkagalaiekckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlil
qilrimesiwetesldlcllpygcistgdkigmieivkdattiakiqqstvgntgafkde
vlnhwlkekspteekfqaaverfvyscagycvatfvlgigdrhndnimitetgnlfhidf
ghilgnyksflginkervpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtn
lliilfsmmlmtgmpqltskedieyirdaltvgkneedakkyfldqievcrdkgwtvqfn
wflhlvl

Sequence, based on observed residues (ATOM records):

>d4hlea4 d.144.1.0 (A:726-1092) automated matches {Human (Homo sapiens) [TaxId: 9606]}
tamlhdftqqvqviemlqkvtldikslydvssqvisqlkqklenlqnsqlpesfrvpydp
glkagalaiekckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlilqilr
imesiwetesldlcllpygcistgdkigmieivkdattiakiqqstvgntgafkdevlnh
wlkekspteekfqaaverfvyscagycvatfvlgigdrhndnimitetgnlfhidfghir
vpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtnlliilfsmmlmtgmpql
tskedieyirdaltvgkneedakkyfldqievcrdkgwtvqfnwflhlvl

Timeline for d4hlea4:

• d4hlea4 first appeared in SCOPe 2.04
  
• d4hlea4 appears in SCOPe 2.06
  
• d4hlea4 appears in the current release, SCOPe 2.08