SCOPe 2.06: Domain d4fhka1: 4fhk A:145-321

Lineage for d4fhka1 (4fhk A:145-321)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.15: beta-Grasp (ubiquitin-like) [54235] (14 superfamilies)
   core: beta(2)-alpha-beta(2); mixed beta-sheet 2143

4. Superfamily d.15.1: Ubiquitin-like [54236] (11 families)

5. Family d.15.1.5: Ras-binding domain, RBD [54263] (14 proteins)
   contains Pfam PF00788 and Pfam PF02196

6. Protein Phoshoinositide 3-kinase (PI3K) [54274] (2 species)
   includes parts of the flanking linkers

7. Species Human (Homo sapiens) [TaxId:9606] [54276] (65 PDB entries)

8. Domain d4fhka1: 4fhk A:145-321 [251974]
   Other proteins in same PDB: d4fhka2, d4fhka3, d4fhka4
   automated match to d1e7ua3
   complexed with 0u0, so4

Details for d4fhka1

PDB Entry: 4fhk, 3 Å

PDB Description: crystal structure of pi3k-gamma in complex with imidazopyridazine 19e

PDB Compounds: (A:) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

SCOPe Domain Sequences for d4fhka1:

Sequence, based on SEQRES records:

>d4fhka1 d.15.1.5 (A:145-321) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens) [TaxId: 9606]}
eesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwvts
kplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkmakkkslmdipes
qseqdfvlrvcgrdeylvgetpiknfqwvrhclkngeeihvvldtppdpaldevrke

Sequence, based on observed residues (ATOM records):

>d4fhka1 d.15.1.5 (A:145-321) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens) [TaxId: 9606]}
eesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwvts
kplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkmdfvlrvcgrdey
lvgetpiknfqwvrhclkngeeihvvldtppdpaldevrke

Timeline for d4fhka1:

• d4fhka1 first appeared in SCOPe 2.04
  
• d4fhka1 appears in SCOPe 2.05
  
• d4fhka1 appears in SCOPe 2.07
  
• d4fhka1 appears in the current release, SCOPe 2.08