SCOPe 2.08: Domain d4f1sa3: 4f1s A:526-725

Lineage for d4f1sa3 (4f1s A:526-725)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.118: alpha-alpha superhelix [48370] (28 superfamilies)
   multihelical; 2 (curved) layers: alpha/alpha; right-handed superhelix

4. Superfamily a.118.1: ARM repeat [48371] (28 families)

5. Family a.118.1.6: Phoshoinositide 3-kinase (PI3K) helical domain [48399] (1 protein)
   automatically mapped to Pfam PF00613
   this is a repeat family; one repeat unit is 1e8y A:598-635 found in domain

6. Protein Phoshoinositide 3-kinase (PI3K) helical domain [48400] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48402] (77 PDB entries)

8. Domain d4f1sa3: 4f1s A:526-725 [251865]
   Other proteins in same PDB: d4f1sa1, d4f1sa2, d4f1sa4
   automated match to d1e7ua1
   complexed with f1s, so4

Details for d4f1sa3

PDB Entry: 4f1s, 3 Å

PDB Description: Crystal structure of human PI3K-gamma in complex with a pyridyl-triazine-sulfonamide inhibitor

PDB Compounds: (A:) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

SCOPe Domain Sequences for d4f1sa3:

Sequence, based on SEQRES records:

>d4f1sa3 a.118.1.6 (A:526-725) Phoshoinositide 3-kinase (PI3K) helical domain {Human (Homo sapiens) [TaxId: 9606]}
pialpkhqptpdpegdrvraempnqlrkqleaiiatdplnpltaedkellwhfryeslkh
pkaypklfssvkwgqqeivaktyqllarrevwdqsaldvgltmqlldcnfsdenvraiav
qklesledddvlhyllqlvqavkfepyhdsalarfllkrglrnkrighflfwflrseiaq
srhyqqrfavileaylrgcg

Sequence, based on observed residues (ATOM records):

>d4f1sa3 a.118.1.6 (A:526-725) Phoshoinositide 3-kinase (PI3K) helical domain {Human (Homo sapiens) [TaxId: 9606]}
pialpkhqaempnqlrkqleaiiatdplnpltaedkellwhfryeslkhpkaypklfssv
kwgqqeivaktyqllarrevwdqsaldvgltmqlldcnfsdenvraiavqklesledddv
lhyllqlvqavkfepyhdsalarfllkrglrnkrighflfwflrseiaqsrhyqqrfavi
leaylrgcg

Timeline for d4f1sa3:

• d4f1sa3 first appeared in SCOPe 2.04
  
• d4f1sa3 appears in SCOPe 2.07