Lineage for d3prea2 (3pre A:353-522)

  1. Root: SCOPe 2.07
  2. 2344607Class b: All beta proteins [48724] (178 folds)
  3. 2368400Fold b.7: C2 domain-like [49561] (5 superfamilies)
    sandwich; 8 strands in 2 sheets; greek-key
  4. 2368401Superfamily b.7.1: C2 domain (Calcium/lipid-binding domain, CaLB) [49562] (3 families) (S)
    two constituent families are related by circular permutation
  5. 2368402Family b.7.1.1: PLC-like (P variant) [49563] (12 proteins)
  6. 2368425Protein Phoshoinositide 3-kinase (PI3K) [49570] (2 species)
  7. 2368426Species Human (Homo sapiens) [TaxId:9606] [49572] (70 PDB entries)
  8. 2368478Domain d3prea2: 3pre A:353-522 [248624]
    Other proteins in same PDB: d3prea1, d3prea3, d3prea4
    automated match to d1e8wa2
    complexed with 3re

Details for d3prea2

PDB Entry: 3pre (more details), 2.91 Å

PDB Description: quinazolines with intra-molecular hydrogen bonding scaffold (imhbs) as pi3k/mtor dual inhibitors.
PDB Compounds: (A:) phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

SCOPe Domain Sequences for d3prea2:

Sequence, based on SEQRES records: (download)

>d3prea2 b.7.1.1 (A:353-522) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens) [TaxId: 9606]}

Sequence, based on observed residues (ATOM records): (download)

>d3prea2 b.7.1.1 (A:353-522) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d3prea2:

Click to download the PDB-style file with coordinates for d3prea2.
(The format of our PDB-style files is described here.)

Timeline for d3prea2: