SCOPe 2.06: Domain d3nzsa2: 3nzs A:353-521

Lineage for d3nzsa2 (3nzs A:353-521)

1. Root: SCOPe 2.06

2. Class b: All beta proteins [48724] (177 folds)

3. Fold b.7: C2 domain-like [49561] (5 superfamilies)
   sandwich; 8 strands in 2 sheets; greek-key

4. Superfamily b.7.1: C2 domain (Calcium/lipid-binding domain, CaLB) [49562] (3 families)
   two constituent families are related by circular permutation

5. Family b.7.1.1: PLC-like (P variant) [49563] (12 proteins)

6. Protein Phoshoinositide 3-kinase (PI3K) [49570] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [49572] (61 PDB entries)

8. Domain d3nzsa2: 3nzs A:353-521 [248104]
   Other proteins in same PDB: d3nzsa1, d3nzsa3, d3nzsa4
   automated match to d1e8wa2
   complexed with nzs

Details for d3nzsa2

PDB Entry: 3nzs, 2.75 Å

PDB Description: Structure-based Optimization of Pyrazolo -Pyrimidine and -Pyridine Inhibitors of PI3-Kinase

PDB Compounds: (A:) phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

SCOPe Domain Sequences for d3nzsa2:

Sequence, based on SEQRES records:

>d3nzsa2 b.7.1.1 (A:353-521) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens) [TaxId: 9606]}
slwdcdrkfrvkirgidipvlprntdltvfveaniqhgqqvlcqrrtspkpfteevlwnv
wlefsikikdlpkgallnlqiycgkapalsskasaespsseskgkvqllyyvnlllidhr
fllrrgeyvlhmwqisgkgedqgsfnadkltsatnpdkensmsisilld

Sequence, based on observed residues (ATOM records):

>d3nzsa2 b.7.1.1 (A:353-521) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens) [TaxId: 9606]}
slwdcdrkfrvkirgidipvlprntdltvfveaniqhgqqvlcqrrtspkpfteevlwnv
wlefsikikdlpkgallnlqiycqllyyvnlllidhrfllrrgeyvlhmwqisfnadklt
satnpdkensmsisilld

Timeline for d3nzsa2:

• d3nzsa2 first appeared in SCOPe 2.04
  
• d3nzsa2 appears in SCOPe 2.05
  
• d3nzsa2 appears in SCOPe 2.07
  
• d3nzsa2 appears in the current release, SCOPe 2.08