SCOPe 2.06: Domain d3lzbb_: 3lzb B:

Lineage for d3lzbb_ (3lzb B:)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (25 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (882 PDB entries)

8. Domain d3lzbb_: 3lzb B: [247561]
   automated match to d2r4ba_
   complexed with iti

Details for d3lzbb_

PDB Entry: 3lzb, 2.7 Å

PDB Description: egfr kinase domain complexed with an imidazo[2,1-b]thiazole inhibitor

PDB Compounds: (B:) Epidermal growth factor receptor

SCOPe Domain Sequences for d3lzbb_:

Sequence, based on SEQRES records:

>d3lzbb_ d.144.1.0 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
llrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkankeilde
ayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqyllnwcvqia
kgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeggkvpikwma
lesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqppictid
vymimrkcwmidadsrpkfreliiefskmardpqrylviqg

Sequence, based on observed residues (ATOM records):

>d3lzbb_ d.144.1.0 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
llrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkankeilde
ayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqyllnwcvqia
kgmnyledrrlvhrdlaarnvlvktpqhvkitdfglkvpikwmalesilhriythqsdvw
sygvtvwelmtfgskpydgipaseissilekgerlpqppictidvymimrkcwmidadsr
pkfreliiefskmardpqrylviqg

Timeline for d3lzbb_:

• d3lzbb_ first appeared in SCOPe 2.04
  
• d3lzbb_ appears in SCOPe 2.05
  
• d3lzbb_ appears in SCOPe 2.07
  
• d3lzbb_ appears in the current release, SCOPe 2.08