Lineage for d3l16a1 (3l16 A:144-321)

  1. Root: SCOPe 2.07
  2. 2494617Class d: Alpha and beta proteins (a+b) [53931] (388 folds)
  3. 2501110Fold d.15: beta-Grasp (ubiquitin-like) [54235] (14 superfamilies)
    core: beta(2)-alpha-beta(2); mixed beta-sheet 2143
  4. 2501111Superfamily d.15.1: Ubiquitin-like [54236] (11 families) (S)
  5. 2502429Family d.15.1.5: Ras-binding domain, RBD [54263] (14 proteins)
    contains Pfam PF00788 and Pfam PF02196
  6. 2502449Protein Phoshoinositide 3-kinase (PI3K) [54274] (2 species)
    includes parts of the flanking linkers
  7. 2502450Species Human (Homo sapiens) [TaxId:9606] [54276] (77 PDB entries)
  8. 2502512Domain d3l16a1: 3l16 A:144-321 [247315]
    Other proteins in same PDB: d3l16a2, d3l16a3, d3l16a4, d3l16a5
    automated match to d1e7ua3
    complexed with jzx

Details for d3l16a1

PDB Entry: 3l16 (more details), 2.9 Å

PDB Description: discovery of (thienopyrimidin-2-yl)aminopyrimidines as potent, selective, and orally available pan-pi3-kinase and dual pan-pi3- kinase/mtor inhibitors for the treatment of cancer
PDB Compounds: (A:) phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

SCOPe Domain Sequences for d3l16a1:

Sequence, based on SEQRES records: (download)

>d3l16a1 d.15.1.5 (A:144-321) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens) [TaxId: 9606]}

Sequence, based on observed residues (ATOM records): (download)

>d3l16a1 d.15.1.5 (A:144-321) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d3l16a1:

Click to download the PDB-style file with coordinates for d3l16a1.
(The format of our PDB-style files is described here.)

Timeline for d3l16a1: