SCOPe 2.06: Domain d2zmda_: 2zmd A:

Lineage for d2zmda_ (2zmd A:)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (25 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (882 PDB entries)

8. Domain d2zmda_: 2zmd A: [244952]
   automated match to d3vqua_
   complexed with 537, 7pe; mutant

Details for d2zmda_

PDB Entry: 2zmd, 2.88 Å

PDB Description: crystal structure of human mps1 catalytic domain t686a mutant in complex with sp600125 inhibitor

PDB Compounds: (A:) Dual specificity protein kinase TTK

SCOPe Domain Sequences for d2zmda_:

Sequence, based on SEQRES records:

>d2zmda_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ecisvkgriysilkqigsggsskvfqvlnekkqiyaikyvnleeadnqtldsyrneiayl
nklqqhsdkiirlydyeitdqyiymvmecgnidlnswlkkkksidpwerksywknmleav
htihqhgivhsdlkpanflivdgmlklidfgianqmqpdttsvvkdsqvgavnymppeai
kdmsssrengkskskispksdvwslgcilyymtygktpfqqiinqisklhaiidpnheie
fpdipekdlqdvlkcclkrdpkqrisipellahpyvqiqt

Sequence, based on observed residues (ATOM records):

>d2zmda_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ecisvkgriysilkqigsggsskvfqvlnekkqiyaikyvnleeadnqtldsyrneiayl
nklqqhsdkiirlydyeitdqyiymvmecgnidlnswlkkkksidpwerksywknmleav
htihqhgivhsdlkpanflivdgmlklidfgianqmdsqvgavnymppeaikdmispksd
vwslgcilyymtygktpfqqiinqisklhaiidpnheiefpdipekdlqdvlkcclkrdp
kqrisipellahpyvqiqt

Timeline for d2zmda_:

• d2zmda_ first appeared in SCOPe 2.04
  
• d2zmda_ appears in SCOPe 2.05
  
• d2zmda_ appears in SCOPe 2.07
  
• d2zmda_ appears in the current release, SCOPe 2.08