Lineage for d2lgca1 (2lgc A:2-354)

  1. Root: SCOPe 2.06
  2. 2170735Class d: Alpha and beta proteins (a+b) [53931] (385 folds)
  3. 2218047Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 2218048Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 2218179Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
    members organized in the groups and subfamiles specified by the comments
  6. 2220075Protein MAP kinase p38 [56129] (2 species)
    CMGC group; ERK/MAPK subfamily; serine/threonine kinase
  7. 2220076Species Human (Homo sapiens) [TaxId:9606] [56130] (185 PDB entries)
  8. 2220276Domain d2lgca1: 2lgc A:2-354 [242873]
    Other proteins in same PDB: d2lgca2
    automated match to d3zyaa_

Details for d2lgca1

PDB Entry: 2lgc (more details)

PDB Description: Joint NMR and X-ray refinement reveals the structure of a novel dibenzo[a,d]cycloheptenone inhibitor/p38 MAP kinase complex in solution
PDB Compounds: (A:) Mitogen-activated protein kinase 14

SCOPe Domain Sequences for d2lgca1:

Sequence; same for both SEQRES and ATOM records: (download)

>d2lgca1 d.144.1.7 (A:2-354) MAP kinase p38 {Human (Homo sapiens) [TaxId: 9606]}
sqerptfyrqelnktiwevperyqnlspvgsgaygsvcaafdtktglrvavkklsrpfqs
iihakrtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqk
ltddhvqfliyqilrglkyihsadiihrdlkpsnlavnedcelkildfglarhtddemtg
yvatrwyrapeimlnwmhynqtvdiwsvgcimaelltgrtlfpgtdhidqlklilrlvgt
pgaellkkissesarnyiqsltqmpkmnfanvfiganplavdllekmlvldsdkritaaq
alahayfaqyhdpddepvadpydqsfesrdllidewksltydevisfvpppld

SCOPe Domain Coordinates for d2lgca1:

Click to download the PDB-style file with coordinates for d2lgca1.
(The format of our PDB-style files is described here.)

Timeline for d2lgca1:

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Domains from same chain:
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d2lgca2