SCOPe 2.06: Domain d2ewyd_: 2ewy D:

Lineage for d2ewyd_ (2ewy D:)

1. Root: SCOPe 2.06

2. Class b: All beta proteins [48724] (177 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.0: automated matches [191552] (1 protein)
   not a true family

6. Protein automated matches [190954] (11 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [193159] (12 PDB entries)

8. Domain d2ewyd_: 2ewy D: [241802]
   automated match to d3zkqa_
   complexed with dbo

Details for d2ewyd_

PDB Entry: 2ewy, 3.1 Å

PDB Description: Crystal structure of human BACE2 in complex with a hydroxyethylenamine transition-state inhibitor

PDB Compounds: (D:) Beta-secretase 2

SCOPe Domain Sequences for d2ewyd_:

Sequence, based on SEQRES records:

>d2ewyd_ b.50.1.0 (D:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
lamvdnlqgdsgrgyylemligtppqklqilvdtgssnfavagtphsyidtyfdtersst
yrskgfdvtvkytqgswtgfvgedlvtipkgfntsflvniatifesenfflpgikwngil
glayatlakpsssletffdslvtqanipnvfsmqmcgaglpvagsgtnggslvlggieps
lykgdiwytpikeewyyqieilkleiggqslnldcreynadkaivdsgttllrlpqkvfd
avveavaraslipefsdgfwtgsqlacwtnsetpwsyfpkisiylrdenssrsfritilp
qlyiqpmmgaglnyecyrfgispstnalvigatvmegfyvifdraqkrvgfaaspcaeia
gaavseisgpfstedvasncvpa

Sequence, based on observed residues (ATOM records):

>d2ewyd_ b.50.1.0 (D:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
lamvdnlqgdsgrgyylemligtppqklqilvdtgssnfavagtphsyidtyfdtersst
yrskgfdvtvkytqgswtgfvgedlvtipkgfntsflvniatifesenfflpgikwngil
glayatlakpsssletffdslvtqanipnvfsmqmcganggslvlggiepslykgdiwyt
pikeewyyqieilkleiggqslnldcreynadkaivdsgttllrlpqkvfdavveavara
slipefsdgfwtgsqlacwtnsetpwsyfpkisiylrdenssrsfritilpqlyiqpmmg
aglnyecyrfgispstnalvigatvmegfyvifdraqkrvgfaaspcaeiagaavseisg
pfstedvasncvpa

Timeline for d2ewyd_:

• d2ewyd_ first appeared in SCOPe 2.04
  
• d2ewyd_ appears in SCOPe 2.05
  
• d2ewyd_ appears in SCOPe 2.07
  
• d2ewyd_ appears in the current release, SCOPe 2.08