Lineage for d4nwmb_ (4nwm B:)

  1. Root: SCOPe 2.07
  2. 2530962Class d: Alpha and beta proteins (a+b) [53931] (388 folds)
  3. 2586062Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 2586063Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 2586210Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
    members organized in the groups and subfamiles specified by the comments
  6. 2589707Protein automated matches [190091] (20 species)
    not a true protein
  7. 2589831Species Human (Homo sapiens) [TaxId:9606] [188447] (892 PDB entries)
  8. 2590548Domain d4nwmb_: 4nwm B: [238271]
    automated match to d4ebwa_
    complexed with 2p5

Details for d4nwmb_

PDB Entry: 4nwm (more details), 2.03 Å

PDB Description: crystal structure of bruton agammaglobulinemia tyrosine kinase complexed with bms-809959 aka 4-tert-butyl-n-[2-me thyl-3-(6-{[4- (morpholine-4-carbonyl)phenyl]amino}-9h- purin-2-yl)phenyl]benzamide
PDB Compounds: (B:) Tyrosine-protein kinase BTK

SCOPe Domain Sequences for d4nwmb_:

Sequence, based on SEQRES records: (download)

>d4nwmb_ d.144.1.7 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
meidpkdltflkelgtgqfgvvkygkwrgqydvaikmikegsmsedefieeakvmmnlsh
eklvqlygvctkqrpifiiteymangcllnylremrhrfqtqqllemckdvceameyles
kqflhrdlaarnclvndqgvvkvsdfglsryvlddeytssvgskfpvrwsppevlmyskf
ssksdiwafgvlmweiyslgkmpyerftnsetaehiaqglrlyrphlasekvytimyscw
hekaderptfkillsnildvmde

Sequence, based on observed residues (ATOM records): (download)

>d4nwmb_ d.144.1.7 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
meidpkdltflkelgtgqfgvvkygkwrgqydvaikmikegsmsedefieeakvmmnlsh
eklvqlygvctkqrpifiiteymangcllnylrerhrfqtqqllemckdvceameylesk
qflhrdlaarnclvndqgvvkvsdfglsryvlddeytssvgskfpvrwsppevlmyskfs
sksdiwafgvlmweiyslgkmpyerftnsetaehiaqglrlyrphlasekvytimyscwh
ekaderptfkillsnildvmde

SCOPe Domain Coordinates for d4nwmb_:

Click to download the PDB-style file with coordinates for d4nwmb_.
(The format of our PDB-style files is described here.)

Timeline for d4nwmb_: