SCOPe 2.08: Domain d4nwma1: 4nwm A:396-657

Lineage for d4nwma1 (4nwm A:396-657)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (20 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (850 PDB entries)

8. Domain d4nwma1: 4nwm A:396-657 [238270]
   Other proteins in same PDB: d4nwma2, d4nwmb2
   automated match to d4ebwa_
   complexed with 2p5

Details for d4nwma1

PDB Entry: 4nwm, 2.03 Å

PDB Description: crystal structure of bruton agammaglobulinemia tyrosine kinase complexed with bms-809959 aka 4-tert-butyl-n-[2-me thyl-3-(6-{[4- (morpholine-4-carbonyl)phenyl]amino}-9h- purin-2-yl)phenyl]benzamide

PDB Compounds: (A:) Tyrosine-protein kinase BTK

SCOPe Domain Sequences for d4nwma1:

Sequence, based on SEQRES records:

>d4nwma1 d.144.1.7 (A:396-657) automated matches {Human (Homo sapiens) [TaxId: 9606]}
eidpkdltflkelgtgqfgvvkygkwrgqydvaikmikegsmsedefieeakvmmnlshe
klvqlygvctkqrpifiiteymangcllnylremrhrfqtqqllemckdvceameylesk
qflhrdlaarnclvndqgvvkvsdfglsryvlddeytssvgskfpvrwsppevlmyskfs
sksdiwafgvlmweiyslgkmpyerftnsetaehiaqglrlyrphlasekvytimyscwh
ekaderptfkillsnildvmde

Sequence, based on observed residues (ATOM records):

>d4nwma1 d.144.1.7 (A:396-657) automated matches {Human (Homo sapiens) [TaxId: 9606]}
eidpkdltflkelgtgqfgvvkygkwrgqydvaikmikegsmsedefieeakvmmnlshe
klvqlygvctkqrpifiiteymangcllnylrerhrfqtqqllemckdvceameyleskq
flhrdlaarnclvndqgvvkvsdfglsryvlddeytssvgskfpvrwsppevlmyskfss
ksdiwafgvlmweiyslgkmpyerftnsetaehiaqglrlyrphlasekvytimyscwhe
kaderptfkillsnildvmde

Timeline for d4nwma1:

• d4nwma1 first appeared in SCOPe 2.03, called d4nwma_
  
• d4nwma1 was called d4nwma_ in SCOPe 2.07