SCOPe 2.05: Domain d4nwka_: 4nwk A:

Lineage for d4nwka_ (4nwk A:)

1. Root: SCOPe 2.05

2. Class b: All beta proteins [48724] (176 folds)

3. Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
   barrel, closed; n=6, S=8; greek-key
   duplication: consists of two domains of the same fold

4. Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families)

5. Family b.47.1.3: Viral proteases [50596] (5 proteins)
   beta sheet in the first domain is opened rather than forms a barrel

6. Protein automated matches [190658] (4 species)
   not a true protein

7. Species Hepatitis C virus subtype 1a [TaxId:31646] [226463] (19 PDB entries)

8. Domain d4nwka_: 4nwk A: [238032]
   automated match to d3sv8a_
   complexed with 2r8, gol, so4, zn

Details for d4nwka_

PDB Entry: 4nwk, 1.62 Å

PDB Description: crystal structure of hepatis c virus protease (ns3) complexed with bms-605339 aka n-(tert-butoxycarbonyl)-3-me thyl-l-valyl-(4r)-n-((1r, 2s)-1-((cyclopropylsulfonyl)carba moyl)-2-vinylcyclopropyl)-4-((6- methoxy-1-isoquinolinyl)ox y)-l-prolinamide

PDB Compounds: (A:) HCV NS3 1a Protease

SCOPe Domain Sequences for d4nwka_:

Sequence; same for both SEQRES and ATOM records:

>d4nwka_ b.47.1.3 (A:) automated matches {Hepatitis C virus subtype 1a [TaxId: 31646]}
gsvvivgrinlsgdtayaqqtrgeegcqetsqtgrdknqvegevqivstatqtflatsin
gvlwtvyhgagtrtiaspkgpvtqmytnvdkdlvgwqapqgsrsltpctcgssdlylvtr
hadvipvrrrgdsrgsllsprpisylkgssggpllcpaghavgifraavctrgvakavdf
ipveslet

Timeline for d4nwka_:

• d4nwka_ first appeared in SCOPe 2.03
  
• d4nwka_ appears in SCOPe 2.04
  
• d4nwka_ appears in SCOPe 2.06
  
• d4nwka_ appears in the current release, SCOPe 2.08