SCOPe 2.03: Domain d4nmhb_: 4nmh B:

Lineage for d4nmhb_ (4nmh B:)

1. Root: SCOPe 2.03

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein 11-beta-hydroxysteroid dehydrogenase 1 [117423] (3 species)

7. Species Mouse (Mus musculus) [TaxId:10090] [141879] (5 PDB entries)
   Uniprot P50172 24-298

8. Domain d4nmhb_: 4nmh B: [238030]
   automated match to d3pdjb_
   complexed with 2kg, ndp, so4

Details for d4nmhb_

PDB Entry: 4nmh, 2.9 Å

PDB Description: 11-beta-HSD1 in complex with a 3,3-Di-methyl-azetidin-2-one

PDB Compounds: (B:) Corticosteroid 11-beta-dehydrogenase isozyme 1

SCOPe Domain Sequences for d4nmhb_:

Sequence; same for both SEQRES and ATOM records:

>d4nmhb_ c.2.1.2 (B:) 11-beta-hydroxysteroid dehydrogenase 1 {Mouse (Mus musculus) [TaxId: 10090]}
efrpemlqgkkvivtgaskgigremayhlskmgahvvltarseeglqkvvsrclelgaas
ahyiagtmedmtfaeqfivkagklmggldmlilnhitqtslslfhddihsvrrvmevnfl
syvvmstaalpmlkqsngsiavisslagkvtypmvapysaskfaldgffstirtelyitk
vnvsitlcvlglidtetamkeisgiinaqaspkeecaleiikgtalrksevyydkspltp
illgnpgrkimeffslryynkdmf

Timeline for d4nmhb_:

• d4nmhb_ is new in SCOPe 2.03-stable
  
• d4nmhb_ appears in SCOPe 2.04
  
• d4nmhb_ appears in the current release, SCOPe 2.08