SCOPe 2.08: Domain d4oq6b1: 4oq6 B:174-321

Lineage for d4oq6b1 (4oq6 B:174-321)

1. Root: SCOPe 2.08

2. Class f: Membrane and cell surface proteins and peptides [56835] (69 folds)

3. Fold f.1: Toxins' membrane translocation domains [56836] (5 superfamilies)
   multi-helical domains of various folds which is thought to unfold in the membrane

4. Superfamily f.1.4: Bcl-2 inhibitors of programmed cell death [56854] (2 families)
   PROVISIONAL CLASSIFICATION, based on structural similarity to the diphtheria toxin domain

5. Family f.1.4.1: Bcl-2 inhibitors of programmed cell death [56855] (11 proteins)
   Pfam PF00452

6. Protein EAT/MCL-1 (Myeloid cell leukemia sequence 1) [118212] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [188549] (62 PDB entries)

8. Domain d4oq6b1: 4oq6 B:174-321 [237716]
   Other proteins in same PDB: d4oq6a2, d4oq6b2
   automated match to d3kj0a_
   complexed with 2uv

Details for d4oq6b1

PDB Entry: 4oq6, 1.81 Å

PDB Description: Crystal Structure of Human MCL-1 Bound to Inhibitor 4-hydroxy-4'-propylbiphenyl-3-carboxylic acid

PDB Compounds: (B:) Induced myeloid leukemia cell differentiation protein Mcl-1

SCOPe Domain Sequences for d4oq6b1:

Sequence, based on SEQRES records:

>d4oq6b1 f.1.4.1 (B:174-321) EAT/MCL-1 (Myeloid cell leukemia sequence 1) {Human (Homo sapiens) [TaxId: 9606]}
lyrqsleiisrylreqatgakdtkpmgrsgatsrkaletlrrvgdgvqrnhetafqgmlr
kldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqescieplaes
itdvlvrtkrdwlvkqrgwdgfveffhv

Sequence, based on observed residues (ATOM records):

>d4oq6b1 f.1.4.1 (B:174-321) EAT/MCL-1 (Myeloid cell leukemia sequence 1) {Human (Homo sapiens) [TaxId: 9606]}
lyrqsleiisrylreqatgakgatsrkaletlrrvgdgvqrnhetafqgmlrkldikned
dvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqescieplaesitdvlvrt
krdwlvkqrgwdgfveffhv

Timeline for d4oq6b1:

• d4oq6b1 first appeared in SCOPe 2.03, called d4oq6b_
  
• d4oq6b1 appears in SCOPe 2.07