SCOPe 2.03: Domain d4ckia_: 4cki A:

Lineage for d4ckia_ (4cki A:)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (18 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (314 PDB entries)

8. Domain d4ckia_: 4cki A: [237248]
   automated match to d2x2ma_
   complexed with adn, fmt

Details for d4ckia_

PDB Entry: 4cki, 2.12 Å

PDB Description: crystal structure of oncogenic ret tyrosine kinase m918t bound to adenosine

PDB Compounds: (A:) proto-oncogene tyrosine-protein kinase receptor ret

SCOPe Domain Sequences for d4ckia_:

Sequence, based on SEQRES records:

>d4ckia_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
gplslsvdafkiledpkwefprknlvlgktlgegefgkvvkatafhlkgragyttvavkm
lkenaspselrdllsefnvlkqvnhphviklygacsqdgpllliveyakygslrgflres
rkvgpgylgsggsrnsssldhpderaltmgdlisfawqisqgmqylaemklvhrdlaarn
ilvaegrkmkisdfglsrdvyeedsyvkrsqgripvkwtaieslfdhiyttqsdvwsfgv
llweivtlggnpypgipperlfnllktghrmerpdncseemyrlmlqcwkqepdkrpvfa
diskdlekmmvkrr

Sequence, based on observed residues (ATOM records):

>d4ckia_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
gplslsvdafkiledpkwefprknlvlgktlgegefgkvvkatafhlkgragyttvavkm
lkenaspselrdllsefnvlkqvnhphviklygacsqdgpllliveyakygslrgflres
rkvderaltmgdlisfawqisqgmqylaemklvhrdlaarnilvaegrkmkisdfglsrd
vyeedsyvkrsqgripvkwtaieslfdhiyttqsdvwsfgvllweivtlggnpypgippe
rlfnllktghrmerpdncseemyrlmlqcwkqepdkrpvfadiskdlekmmvkrr

Timeline for d4ckia_:

• d4ckia_ is new in SCOPe 2.03-stable
  
• d4ckia_ appears in SCOPe 2.04
  
• d4ckia_ appears in the current release, SCOPe 2.08, called d4ckia1