SCOPe 2.03: Domain d4o0rb_: 4o0r B:

Lineage for d4o0rb_ (4o0r B:)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (18 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (314 PDB entries)

8. Domain d4o0rb_: 4o0r B: [236941]
   automated match to d2c30a_
   complexed with x4z

Details for d4o0rb_

PDB Entry: 4o0r, 2.4 Å

PDB Description: back pocket flexibility provides group-ii pak selectivity for type 1 kinase inhibitors

PDB Compounds: (B:) Serine/threonine-protein kinase PAK 1

SCOPe Domain Sequences for d4o0rb_:

Sequence, based on SEQRES records:

>d4o0rb_ d.144.1.0 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
sdeeileklrsivsvgdpkkkytrfekigqgasgtvytamdvatgqevaikqmnlqqqpk
keliineilvmrenknpnivnyldsylvgdelwvvmeylaggsltdvvtetcmdegqiaa
vcreclqaleflhsnqvihrniksdnillgmdgsvkltdfgfcaqitpeqskrsemvgtp
ywmapevvtrkaygpkvdiwslgimaiemiegeppylnenplralyliatngtpelqnpe
klsaifrdflnrclemdvekrgsakellqhqflkiakplssltpliaaakeatk

Sequence, based on observed residues (ATOM records):

>d4o0rb_ d.144.1.0 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
sdeeileklrsivsvgdpkkkytrfekigqgasgtvytamdvatgqevaikqmnlqkeli
ineilvmrenknpnivnyldsylvgdelwvvmeylaggsltdvvtetcmdegqiaavcre
clqaleflhsnqvihrniksdnillgmdgsvkltdfgqskrsemvgtpywmapevvtrka
ygpkvdiwslgimaiemiegeppylnenplralyliatngtpelqnpeklsaifrdflnr
clemdvekrgsakellqhqflkiakplssltpliaaakeatk

Timeline for d4o0rb_:

• d4o0rb_ is new in SCOPe 2.03-stable
  
• d4o0rb_ appears in SCOPe 2.04
  
• d4o0rb_ appears in the current release, SCOPe 2.08