SCOPe 2.04: Domain d4l7sa_: 4l7s A:

Lineage for d4l7sa_ (4l7s A:)

1. Root: SCOPe 2.04

2. Class d: Alpha and beta proteins (a+b) [53931] (380 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Tyrosine-protein kinase Itk/Tsk [111194] (1 species)
   PTK group; Tec/Atk subfamily; non-membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [111195] (28 PDB entries)
   Uniprot Q08881 357-619

8. Domain d4l7sa_: 4l7s A: [236195]
   automated match to d4kioc_
   complexed with g7k, so4; mutant

Details for d4l7sa_

PDB Entry: 4l7s, 2.03 Å

PDB Description: Kinase domain mutant of human Itk in complex with an aminobenzothiazole inhibitor

PDB Compounds: (A:) Tyrosine-protein kinase ITK/TSK

SCOPe Domain Sequences for d4l7sa_:

Sequence, based on SEQRES records:

>d4l7sa_ d.144.1.7 (A:) Tyrosine-protein kinase Itk/Tsk {Human (Homo sapiens) [TaxId: 9606]}
gsvidpseltfvqeigsgqfglvhlgywlnkdkvaiktiregamseedfieeaevmmkls
hpklvqlygvcleqapiclvfefmehgclsdylrtqrglfaaetllgmcldvcegmayle
eacvihrdlaarnclvgenqvikvsdfgmtrfvlddqetsstgtkfpvkwaspevfsfsr
yssksdvwsfgvlmwevfsegkipyenrsnsevvedistgfrlykprlasthvyqimnhc
wkerpedrpafsrllrqlaeiaesgl

Sequence, based on observed residues (ATOM records):

>d4l7sa_ d.144.1.7 (A:) Tyrosine-protein kinase Itk/Tsk {Human (Homo sapiens) [TaxId: 9606]}
gsvidpseltfvqeigsgqfglvhlgywlnkdkvaiktiregamseedfieeaevmmkls
hpklvqlygvcleqapiclvfefmehgclsdylrtqrglfaaetllgmcldvcegmayle
eacvihrdlaarnclvgenqvikvsdfgmtpvkwaspevfsfsryssksdvwsfgvlmwe
vfsegkipyenrsnsevvedistgfrlykprlasthvyqimnhcwkerpedrpafsrllr
qlaeiaesgl

Timeline for d4l7sa_:

• d4l7sa_ first appeared in SCOPe 2.03
  
• d4l7sa_ appears in SCOPe 2.05
  
• d4l7sa_ appears in the current release, SCOPe 2.08, called d4l7sa1