SCOPe 2.08: Domain d4kb8a_: 4kb8 A:

Lineage for d4kb8a_ (4kb8 A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Casein kinase-1, CK1 [56139] (4 species)
   OPK group; CKI subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [224941] (25 PDB entries)

8. Domain d4kb8a_: 4kb8 A: [235134]
   automated match to d4kbad_
   complexed with 1qn, 1qo, so4

Details for d4kb8a_

PDB Entry: 4kb8, 1.95 Å

PDB Description: ck1d in complex with 1-{4-[3-(4-fluorophenyl)-1-methyl-1h-pyrazol-4-yl]pyridin-2-yl}-n-methylmethanamine ligand

PDB Compounds: (A:) Casein kinase I isoform delta

SCOPe Domain Sequences for d4kb8a_:

Sequence, based on SEQRES records:

>d4kb8a_ d.144.1.7 (A:) Casein kinase-1, CK1 {Human (Homo sapiens) [TaxId: 9606]}
lrvgnryrlgrkigsgsfgdiylgtdiaageevaiklecvktkhpqlhieskiykmmqgg
vgiptirwcgaegdynvmvmellgpsledlfnfcsrkfslktvllladqmisrieyihsk
nfihrdvkpdnflmglgkkgnlvyiidfglakkyrdarthqhipyrenknltgtaryasi
nthlgieqsrrddleslgyvlmyfnlgslpwqglkaatkrqkyerisekkmstpievlck
gypsefatylnfcrslrfddkpdysylrqlfrnlfhrqgfsydyvfdwnml

Sequence, based on observed residues (ATOM records):

>d4kb8a_ d.144.1.7 (A:) Casein kinase-1, CK1 {Human (Homo sapiens) [TaxId: 9606]}
lrvgnryrlgrkigsgsfgdiylgtdiaageevaiklecvktkhpqlhieskiykmmqgg
vgiptirwcgaegdynvmvmellgpsledlfnfcsrkfslktvllladqmisrieyihsk
nfihrdvkpdnflmglgkkgnlvyiidfglakkygtaryasinthlgieqsrrddleslg
yvlmyfnlgslpwqglkerisekkmstpievlckgypsefatylnfcrslrfddkpdysy
lrqlfrnlfhrqgfsydyvfdwnml

Timeline for d4kb8a_:

• d4kb8a_ first appeared in SCOPe 2.03
  
• d4kb8a_ appears in SCOPe 2.07