SCOPe 2.03: Domain d4j95b_: 4j95 B:

Lineage for d4j95b_ (4j95 B:)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Fibroblast growth factor receptor 2 [75562] (1 species)
   PTK group; FGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [75563] (11 PDB entries)
   Uniprot P21802 467-765

8. Domain d4j95b_: 4j95 B: [234944]
   automated match to d2pvyb_
   complexed with acp, so4; mutant

Details for d4j95b_

PDB Entry: 4j95, 2.38 Å

PDB Description: crystal structure of fgf receptor 2 (fgfr2) kinase domain harboring the pathogenic k659n mutation responsible for an unclassified craniosynostosis syndrome in space group c2.

PDB Compounds: (B:) Fibroblast growth factor receptor 2

SCOPe Domain Sequences for d4j95b_:

Sequence, based on SEQRES records:

>d4j95b_ d.144.1.7 (B:) Fibroblast growth factor receptor 2 {Human (Homo sapiens) [TaxId: 9606]}
lpedpkwefprdkltlgkplgegafgqvvmaeavgidkdkpkeavtvavkmlkddatekd
lsdlvsememmkmigkhkniinllgactqdgplyviveyaskgnlreylrarrppgmeys
ydinrvpeeqmtfkdlvsctyqlargmeylasqkcihrdlaarnvlvtennvmkiadfgl
ardinnidyyknttngrlpvkwmapealfdrvythqsdvwsfgvlmweiftlggspypgi
pveelfkllkeghrmdkpanctnelymmmrdcwhavpsqrptfkqlvedldriltlt

Sequence, based on observed residues (ATOM records):

>d4j95b_ d.144.1.7 (B:) Fibroblast growth factor receptor 2 {Human (Homo sapiens) [TaxId: 9606]}
lpedpkwefprdkltlgkplgegafgqvvmaeavgidkdkpkeavtvavkmlkddatekd
lsdlvsememmkmigkhkniinllgactqdgplyviveyaskgnlreylrarrpqmtfkd
lvsctyqlargmeylasqkcihrdlaarnvlvtennvmkiadfglardinnidyyknttn
grlpvkwmapealfdrvythqsdvwsfgvlmweiftlggspypgipveelfkllkeghrm
dkpanctnelymmmrdcwhavpsqrptfkqlvedldriltlt

Timeline for d4j95b_:

• d4j95b_ is new in SCOPe 2.03-stable
  
• d4j95b_ appears in SCOPe 2.04
  
• d4j95b_ appears in the current release, SCOPe 2.08