SCOPe 2.03: Domain d4igfa_: 4igf A:

Lineage for d4igfa_ (4igf A:)

1. Root: SCOPe 2.03

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein automated matches [190085] (38 species)
   not a true protein

7. Species Plasmodium falciparum [TaxId:36329] [228763] (2 PDB entries)

8. Domain d4igfa_: 4igf A: [234848]
   automated match to d4igea_
   complexed with chv, gol, nad, so4

Details for d4igfa_

PDB Entry: 4igf, 2.3 Å

PDB Description: crystal structure of plasmodium falciparum fabi complexed with nad and inhibitor 3-(4-chloro-2-hydroxyphenoxy)-7-hydroxy-2h-chromen-2-one

PDB Compounds: (A:) enoyl-acyl carrier reductase

SCOPe Domain Sequences for d4igfa_:

Sequence, based on SEQRES records:

>d4igfa_ c.2.1.2 (A:) automated matches {Plasmodium falciparum [TaxId: 36329]}
edicfiagigdtngygwgiakelskrnvkiifgiwppvynifmknykngkfdndmiidkd
kkmnildmlpfdasfdtandideetknnkrynmlqnytiedvanlihqkygkinmlvhsl
anakevqkdllntsrkgyldalskssyslislckyfvnimkpqssiisltyhasqkvvpg
ygggmssakaalesdtrvlayhlgrnynirintisagplksraatainklnntyenntnq
nknrnshdvhnimnnsgekeekknsasqnytfidyaieysekyaplrqkllstdigsvas
fllsresraitgqtiyvdnglnimflpd

Sequence, based on observed residues (ATOM records):

>d4igfa_ c.2.1.2 (A:) automated matches {Plasmodium falciparum [TaxId: 36329]}
edicfiagigdtngygwgiakelskrnvkiifgiwppvynifmknykngkfdndmiidkd
kkmnildmlpfdasfdtandidetknnkrynmlqnytiedvanlihqkygkinmlvhsla
nakevqkdllntsrkgyldalskssyslislckyfvnimkpqssiisltyhasqkvvpgy
gggmssakaalesdtrvlayhlgrnynirintisagplksfidyaieysekyaplrqkll
stdigsvasfllsresraitgqtiyvdnglnimflpd

Timeline for d4igfa_:

• d4igfa_ is new in SCOPe 2.03-stable
  
• d4igfa_ appears in SCOPe 2.04
  
• d4igfa_ appears in the current release, SCOPe 2.08