SCOPe 2.05: Domain d4hevb_: 4hev B:

Lineage for d4hevb_ (4hev B:)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.92: Zincin-like [55485] (2 superfamilies)
   contains mixed beta sheet with connection over free side of the sheet

4. Superfamily d.92.1: Metalloproteases ("zincins"), catalytic domain [55486] (18 families)

5. Family d.92.1.7: Clostridium neurotoxins, catalytic domain [55512] (2 proteins)

6. Protein Botulinum neurotoxin [55513] (4 species)

7. Species Clostridium botulinum, serotype A [TaxId:1491] [55514] (26 PDB entries)
   Uniprot P10845 1-419

8. Domain d4hevb_: 4hev B: [234647]
   automated match to d4ej5a_
   complexed with axm, zn

Details for d4hevb_

PDB Entry: 4hev, 2.5 Å

PDB Description: Clostridium Botulinum Serotype A Light Chain Inhibited By Adamantane Hydroxamate

PDB Compounds: (B:) botulinum neurotoxin type a light chain

SCOPe Domain Sequences for d4hevb_:

Sequence, based on SEQRES records:

>d4hevb_ d.92.1.7 (B:) Botulinum neurotoxin {Clostridium botulinum, serotype A [TaxId: 1491]}
ssglvprgshmqfvnkqfnykdpvngvdiayikipnvgqmqpvkafkihnkiwviperdt
ftnpeegdlnpppeakqvpvsyydstylstdnekdnylkgvtklferiystdlgrmllts
ivrgipfwggstidtelkvidtncinviqpdgsyrseelnlviigpsadiiqfecksfgh
evlnltrngygstqyirfspdftfgfeeslevdtnpllgagkfatdpavtlahelihagh
rlygiainpnrvfkvntnayyemsglevsfeelrtfgghdakfidslqenefrlyyynkf
kdiastlnkaksivgttaslqymknvfkekyllsedtsgkfsvdklkfdklykmlteiyt
ednfvkffkvlnrktylnfdkavfkinivpkvnytiydgfnlrntnlaanfngqnteinn
mnftkl

Sequence, based on observed residues (ATOM records):

>d4hevb_ d.92.1.7 (B:) Botulinum neurotoxin {Clostridium botulinum, serotype A [TaxId: 1491]}
ssglvprgshmqfvnkqfnykdpvngvdiayikipqmqpvkafkihnkiwviperdtftn
peegdlnppvsyydstylstdnekdnylkgvtklferiystdlgrmlltsivrgipfwgg
stidtelkvidtncinviqpdgsyrseelnlviigpsadiiqfecksfghevlnltrngy
gstqyirfspdftfgfeesgagkfatdpavtlahelihaghrlygiainpnrvevsfeel
rtfgghdakfidslqenefrlyyynkfkdiastlnkaksivgttaslqymknvfkekyll
sedtsgkfsvdklkfdklykmlteiytednfvkffkvlnrktylnfdkavfkinivpkvn
ytiydgfnlrntnlaanfngqnteinnmnftkl

Timeline for d4hevb_:

• d4hevb_ first appeared in SCOPe 2.03
  
• d4hevb_ appears in SCOPe 2.04
  
• d4hevb_ is called d4hevb1 in SCOPe 2.06
  
• d4hevb_ appears in the current release, SCOPe 2.08, called d4hevb1