SCOPe 2.03: Domain d4ae6a_: 4ae6 A:

Lineage for d4ae6a_ (4ae6 A:)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (11 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (418 PDB entries)

8. Domain d4ae6a_: 4ae6 A: [234057]
   automated match to d4ae6b_
   complexed with act

Details for d4ae6a_

PDB Entry: 4ae6, 2.1 Å

PDB Description: A Crystal Structure of the Sperm Specific Isoform of Protein Kinase A (PKA) Subunit CalphaS Reveals a Binding Pocket for Hydrophobic Moieties

PDB Compounds: (A:) camp-dependent protein kinase catalytic subunit alpha 2

SCOPe Domain Sequences for d4ae6a_:

Sequence, based on SEQRES records:

>d4ae6a_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ssdvkeflakakedflkkwespaqntahldqferiktlgtgsfgrvmlvkhketgnhyam
kildkqkvvklkqiehtlnekrilqavnfpflvklefsfkdnsnlymvmeyvpggemfsh
lrrigrfsepharfyaaqivltfeylhsldliyrdlkpenllidqqgyiqvtdfgfakrv
kgrtwtlcgtpeylapeiilskgynkavdwwalgvliyemaagyppffadqpiqiyekiv
sgkvrfpshfssdlkdllrnllqvdltkrfgnlkngvndiknhkwfattdwiaiyqrkve
apfipkfkgpgdtsnfddyeeeeirvsinekcgkefsef

Sequence, based on observed residues (ATOM records):

>d4ae6a_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ssdvkeflakakedflkkwespaqntahldqferiktlgtgsfgrvmlvkhketgnhyam
kildkqkvvklkqiehtlnekrilqavnfpflvklefsfkdnsnlymvmeyvpggemfsh
lrrigrfsepharfyaaqivltfeylhsldliyrdlkpenllidqqgyiqvtdfgfakrv
kgrtwtlcgtpeylapeiilskgynkavdwwalgvliyemaagyppffadqpiqiyekiv
sgkvrfpshfssdlkdllrnllqvdltkrfgnlkngvndiknhkwfattdwiaiyqrkve
apfipkfvsinekcgkefsef

Timeline for d4ae6a_:

• d4ae6a_ is new in SCOPe 2.03-stable
  
• d4ae6a_ appears in SCOPe 2.04
  
• d4ae6a_ appears in the current release, SCOPe 2.08