SCOPe 2.08: Domain d3wixd_: 3wix D:

Lineage for d3wixd_ (3wix D:)

1. Root: SCOPe 2.08

2. Class f: Membrane and cell surface proteins and peptides [56835] (69 folds)

3. Fold f.1: Toxins' membrane translocation domains [56836] (5 superfamilies)
   multi-helical domains of various folds which is thought to unfold in the membrane

4. Superfamily f.1.4: Bcl-2 inhibitors of programmed cell death [56854] (2 families)
   PROVISIONAL CLASSIFICATION, based on structural similarity to the diphtheria toxin domain

5. Family f.1.4.1: Bcl-2 inhibitors of programmed cell death [56855] (11 proteins)
   Pfam PF00452

6. Protein EAT/MCL-1 (Myeloid cell leukemia sequence 1) [118212] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [188549] (62 PDB entries)

8. Domain d3wixd_: 3wix D: [233966]
   automated match to d3wiye_
   complexed with lc3

Details for d3wixd_

PDB Entry: 3wix, 1.9 Å

PDB Description: Crystal structure of Mcl-1 in complex with compound 4

PDB Compounds: (D:) Induced myeloid leukemia cell differentiation protein Mcl-1

SCOPe Domain Sequences for d3wixd_:

Sequence, based on SEQRES records:

>d3wixd_ f.1.4.1 (D:) EAT/MCL-1 (Myeloid cell leukemia sequence 1) {Human (Homo sapiens) [TaxId: 9606]}
delyrqsleiisrylreqatgakdtkpmgrsgatsrkaletlrrvgdgvqrnhetafqgm
lrkldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqesciepla
esitdvlvrtkrdwlvkqrgwdgfveffhv

Sequence, based on observed residues (ATOM records):

>d3wixd_ f.1.4.1 (D:) EAT/MCL-1 (Myeloid cell leukemia sequence 1) {Human (Homo sapiens) [TaxId: 9606]}
delyrqsleiisrylreqatgakdgatsrkaletlrrvgdgvqrnhetafqgmlrkldik
neddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqescieplaesitdvl
vrtkrdwlvkqrgwdgfveffhv

Timeline for d3wixd_:

• d3wixd_ first appeared in SCOPe 2.03
  
• d3wixd_ appears in SCOPe 2.07