Lineage for d3l1sa_ (3l1s A:)

  1. Root: SCOPe 2.03
  2. 1396887Class d: Alpha and beta proteins (a+b) [53931] (376 folds)
  3. 1433536Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 1433537Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 1433619Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
    members organized in the groups and subfamiles specified by the comments
  6. 1434708Protein Glycogen synthase kinase-3 beta (Gsk3b) [69823] (1 species)
    CMGC group; GSK3 subfamily; serine/threonine kinase
  7. 1434709Species Human (Homo sapiens) [TaxId:9606] [69824] (30 PDB entries)
    Uniprot P49841 35-383 ! Uniprot P49841 35-384
  8. 1434747Domain d3l1sa_: 3l1s A: [232755]
    automated match to d3i4ba_
    complexed with po4, z92

Details for d3l1sa_

PDB Entry: 3l1s (more details), 2.9 Å

PDB Description: 3-aryl-4-(arylhydrazono)-1h-pyrazol-5-ones: highly ligand efficient and potent inhibitors of gsk3
PDB Compounds: (A:) Glycogen synthase kinase-3 beta

SCOPe Domain Sequences for d3l1sa_:

Sequence, based on SEQRES records: (download)

>d3l1sa_ d.144.1.7 (A:) Glycogen synthase kinase-3 beta (Gsk3b) {Human (Homo sapiens) [TaxId: 9606]}
smkvsrdkdgskvttvvatpgqgpdrpqevsytdtkvigngsfgvvyqaklcdsgelvai
kkvlqdkrfknrelqimrkldhcnivrlryffyssgekkdevylnlvldyvpetvyrvar
hysrakqtlpviyvklymyqlfrslayihsfgichrdikpqnllldpdtavlklcdfgsa
kqlvrgepnvsyicsryyrapelifgatdytssidvwsagcvlaelllgqpifpgdsgvd
qlveiikvlgtptreqiremnpnytefkfpqikahpwtkvfrprtppeaialcsrlleyt
ptarltpleacahsffdelrdpnvklpngrdtpalfnfttqelssnpplatilipphari

Sequence, based on observed residues (ATOM records): (download)

>d3l1sa_ d.144.1.7 (A:) Glycogen synthase kinase-3 beta (Gsk3b) {Human (Homo sapiens) [TaxId: 9606]}
smkvsrdskvttvvatpgqgpdrpqevsytdtkvigngsfgvvyqaklcdsgelvaikkv
lqdkrfknrelqimrkldhcnivrlryffysvylnlvldyvpetvyrvarhysrakqtlp
viyvklymyqlfrslayihsfgichrdikpqnllldpdtavlklcdfgsakqlvrgepnv
syicsryyrapelifgatdytssidvwsagcvlaelllgqpifpgdsgvdqlveiikvlg
tptreqiremnpwtkvfrprtppeaialcsrlleytptarltpleacahsffdelrdpnv
klpngrdtpalfnfttqelssnpplatilipphari

SCOPe Domain Coordinates for d3l1sa_:

Click to download the PDB-style file with coordinates for d3l1sa_.
(The format of our PDB-style files is described here.)

Timeline for d3l1sa_: