SCOPe 2.04: Domain d3l1sb_: 3l1s B:

Lineage for d3l1sb_ (3l1s B:)

1. Root: SCOPe 2.04

2. Class d: Alpha and beta proteins (a+b) [53931] (380 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Glycogen synthase kinase-3 beta (Gsk3b) [69823] (1 species)
   CMGC group; GSK3 subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [69824] (35 PDB entries)
   Uniprot P49841 35-383 ! Uniprot P49841 35-384

8. Domain d3l1sb_: 3l1s B: [232754]
   automated match to d1q5ka_
   complexed with po4, z92

Details for d3l1sb_

PDB Entry: 3l1s, 2.9 Å

PDB Description: 3-aryl-4-(arylhydrazono)-1h-pyrazol-5-ones: highly ligand efficient and potent inhibitors of gsk3

PDB Compounds: (B:) Glycogen synthase kinase-3 beta

SCOPe Domain Sequences for d3l1sb_:

Sequence, based on SEQRES records:

>d3l1sb_ d.144.1.7 (B:) Glycogen synthase kinase-3 beta (Gsk3b) {Human (Homo sapiens) [TaxId: 9606]}
kvttvvatpgqgpdrpqevsytdtkvigngsfgvvyqaklcdsgelvaikkvlqdkrfkn
relqimrkldhcnivrlryffyssgekkdevylnlvldyvpetvyrvarhysrakqtlpv
iyvklymyqlfrslayihsfgichrdikpqnllldpdtavlklcdfgsakqlvrgepnvs
yicsryyrapelifgatdytssidvwsagcvlaelllgqpifpgdsgvdqlveiikvlgt
ptreqiremnpnytefkfpqikahpwtkvfrprtppeaialcsrlleytptarltpleac
ahsffdelrdpnvklpngrdtpalfnfttqelssnpplatilippha

Sequence, based on observed residues (ATOM records):

>d3l1sb_ d.144.1.7 (B:) Glycogen synthase kinase-3 beta (Gsk3b) {Human (Homo sapiens) [TaxId: 9606]}
kvttvvatpgqgpdrpqevsytdtkvigngsfgvvyqaklcdsgelvaikkvlqdkrfkn
relqimrkldhcnivrlryffysskkdevylnlvldyvpetvyrvarhysrakqtlpviy
vklymyqlfrslayihsfgichrdikpqnllldpdtavlklcdfgsakqlvrgepnvsyi
csryyrapelifgatdytssidvwsagcvlaelllgqpifpgdsgvdqlveiikvlgtpt
reqiremnwtkvfrprtppeaialcsrlleytptarltpleacahsffdelrdpnvklpn
grdtpalfnfttqelssnpplatilippha

Timeline for d3l1sb_:

• d3l1sb_ first appeared in SCOPe 2.03
  
• d3l1sb_ appears in SCOPe 2.05
  
• d3l1sb_ appears in the current release, SCOPe 2.08