SCOPe 2.04: Domain d3h1da_: 3h1d A:

Lineage for d3h1da_ (3h1d A:)

1. Root: SCOPe 2.04

2. Class d: Alpha and beta proteins (a+b) [53931] (380 folds)

3. Fold d.148: Hect, E3 ligase catalytic domain [56203] (1 superfamily)
   consists of two alpha+beta domains; the N-terminal domain is array of helices and beta-hairpins; the C-terminal domain is an a/b sandwich with one left-handed beta-alpha(n)-beta unit; conformational flexibility of domain orientation

4. Superfamily d.148.1: Hect, E3 ligase catalytic domain [56204] (2 families)
   automatically mapped to Pfam PF00632

5. Family d.148.1.0: automated matches [227207] (1 protein)
   not a true family

6. Protein automated matches [226939] (1 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [225255] (8 PDB entries)

8. Domain d3h1da_: 3h1d A: [232357]
   automated match to d2onia_
   complexed with so4

Details for d3h1da_

PDB Entry: 3h1d, 1.89 Å

PDB Description: structure of the huwe1 hect domain

PDB Compounds: (A:) E3 ubiquitin-protein ligase HUWE1

SCOPe Domain Sequences for d3h1da_:

Sequence, based on SEQRES records:

>d3h1da_ d.148.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ssglevlfqgphmdfdvkrkyfrqelerldeglrkedmavhvrrdhvfedsyrelhrksp
eemknrlyivfegeegqdaggllrewymiisremfnpmyalfrtspgdrvtytinpssha
npnhlsyfkfvgrivakavydnrllecyftrsfykhilgksvrytdmesedyhfyqglvy
llendvstlgydltfstevqefgvaevrdlkpnganilvteenkkeyvhlvcqmrmtgai
rkqlaaflegfyeiipkrlisifteqelellisglptididdlksnteyhkyqsnsiqiq
wfwralrsfdqadrakflqfvtgtskvplqgfaalegmngiqkfqihrddrstdrlpsah
tcfnqldlpayesfeklrhmlllaiqe

Sequence, based on observed residues (ATOM records):

>d3h1da_ d.148.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ssglevlfqgphmdfdvkrkyfrqelerldeglrkedmavhvrrdhvfedsyrelhrksp
eemknrlyivfegeegqdaggllrewymiisremfnpmyalfrtspgdrvtytinpsnhl
syfkfvgrivakavydnrllecyftrsfykhilgksvrytdmesedyhfyqglvyllend
vstlgydltfstevqefgvaevrdlkpnganilvteenkkeyvhlvcqmrmtgairkqla
aflegfyeiipkrlisifteqelellisglptididdlksnteyhkyqsnsiqiqwfwra
lrsfdqadrakflqfvtgtskvplqgfaalegmngiqkfqihrddrstdrlpsahtcfnq
ldlpayesfeklrhmlllaiqe

Timeline for d3h1da_:

• d3h1da_ first appeared in SCOPe 2.03
  
• d3h1da_ appears in SCOPe 2.05
  
• d3h1da_ appears in the current release, SCOPe 2.08, called d3h1da1