Lineage for d2pzfa1 (2pzf A:387-646)

  1. Root: SCOPe 2.08
  2. 2826024Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2865683Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
    3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes
  4. 2865684Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (27 families) (S)
    division into families based on beta-sheet topologies
  5. 2870122Family c.37.1.12: ABC transporter ATPase domain-like [52686] (25 proteins)
    there are two additional subdomains inserted into the central core that has a RecA-like topology
    missing some secondary structures that made up less than one-third of the common domain
  6. 2870138Protein Cystic fibrosis transmembrane conductance regulator, CFTR, nucleotide-binding domain [102378] (2 species)
  7. 2870139Species Human (Homo sapiens) [TaxId:9606] [117543] (26 PDB entries)
    Uniprot P13569 389-671
  8. 2870158Domain d2pzfa1: 2pzf A:387-646 [231180]
    Other proteins in same PDB: d2pzfa2
    automated match to d2pzfb_
    complexed with atp, mg

Details for d2pzfa1

PDB Entry: 2pzf (more details), 2 Å

PDB Description: minimal human cftr first nucleotide binding domain as a head-to-tail dimer with delta f508
PDB Compounds: (A:) Cystic fibrosis transmembrane conductance regulator

SCOPe Domain Sequences for d2pzfa1:

Sequence, based on SEQRES records: (download)

>d2pzfa1 c.37.1.12 (A:387-646) Cystic fibrosis transmembrane conductance regulator, CFTR, nucleotide-binding domain {Human (Homo sapiens) [TaxId: 9606]}
ltttevvmenvtafweeggtpvlkdinfkiergqllavagstgagktsllmmimgeleps
egkikhsgrisfcsqfswimpgtikeniigvsydeyryrsvikacqleediskfaekdni
vlgeggitlsggqrarislaravykdadlylldspfgyldvltekeifescvcklmankt
rilvtskmehlkkadkililhegssyfygtfselqnlqpdfssklmg

Sequence, based on observed residues (ATOM records): (download)

>d2pzfa1 c.37.1.12 (A:387-646) Cystic fibrosis transmembrane conductance regulator, CFTR, nucleotide-binding domain {Human (Homo sapiens) [TaxId: 9606]}
ltttevvmenvtafwggtpvlkdinfkiergqllavagstgagktsllmmimgelepseg
kikhsgrisfcsqfswimpgtikeniigvsydeyryrsvikacqleediskfaekdnivl
geggitlsggqrarislaravykdadlylldspfgyldvltekeifescvcklmanktri
lvtskmehlkkadkililhegssyfygtfselqnldfssklmg

SCOPe Domain Coordinates for d2pzfa1:

Click to download the PDB-style file with coordinates for d2pzfa1.
(The format of our PDB-style files is described here.)

Timeline for d2pzfa1:

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Domains from same chain:
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d2pzfa2
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Domains from other chains:
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d2pzfb_