SCOPe 2.06: Domain d4i9za_: 4i9z A:

Lineage for d4i9za_ (4i9z A:)

1. Root: SCOPe 2.06

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.211: HD-domain/PDEase-like [109603] (1 superfamily)
   multihelical; consists of two different alpha-helical bundles

4. Superfamily a.211.1: HD-domain/PDEase-like [109604] (6 families)

5. Family a.211.1.2: PDEase [48548] (7 proteins)
   Pfam PF00233; multihelical; can be divided into three subdomains

6. Protein automated matches [190370] (1 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187208] (27 PDB entries)

8. Domain d4i9za_: 4i9z A: [230252]
   automated match to d3tsea_
   complexed with 5ba, mg, peg, zn

Details for d4i9za_

PDB Entry: 4i9z, 2.08 Å

PDB Description: Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors

PDB Compounds: (A:) cGMP-specific 3',5'-cyclic phosphodiesterase

SCOPe Domain Sequences for d4i9za_:

Sequence, based on SEQRES records:

>d4i9za_ a.211.1.2 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
eetrelqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqmkhev
lcrwilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaalshd
ldhrgvnnsyiqrsehplaqlychsimehhhfdqclmilnspgnqilsglsieeykttlk
iikqailatdlalyikrrgeffelirknqfnledphqkelflamlmtacdlsaitkpwpi
qqriaelvateffdqgdrerkelnieptdlmnrekknkipsmqvgfidaiclqlyealth
vsedcfplldgcrknrqkwqalae

Sequence, based on observed residues (ATOM records):

>d4i9za_ a.211.1.2 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
eetrelqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqmkhev
lcrwilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaalshd
ldhrgvnnsylaqlychsimehhhfdqclmilnspgnqilsglsieeykttlkiikqail
atdlalyikrrgeffelirknqfnledphqkelflamlmtacdlsaitkpwpiqqriael
vateffdknkipsmqvgfidaiclqlyealthvsedcfplldgcrknrqkwqalae

Timeline for d4i9za_:

• d4i9za_ first appeared in SCOPe 2.03
  
• d4i9za_ appears in SCOPe 2.05
  
• d4i9za_ appears in SCOPe 2.07
  
• d4i9za_ appears in the current release, SCOPe 2.08