SCOPe 2.08: Domain d4ncsa1: 4ncs A:4-377

Lineage for d4ncsa1 (4ncs A:4-377)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.68: 6-bladed beta-propeller [50938] (11 superfamilies)
   consists of six 4-stranded beta-sheet motifs; meander

4. Superfamily b.68.1: Sialidases [50939] (3 families)

5. Family b.68.1.1: Sialidases (neuraminidases) [50940] (10 proteins)

6. Protein automated matches [193245] (21 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [228885] (2 PDB entries)

8. Domain d4ncsa1: 4ncs A:4-377 [230156]
   Other proteins in same PDB: d4ncsa2
   automated match to d4nc5a_
   complexed with fsr, po4

Details for d4ncsa1

PDB Entry: 4ncs, 2.2 Å

PDB Description: human sialidase 2 in complex with 2,3-difluorosialic acid (covalent intermediate)

PDB Compounds: (A:) Sialidase-2

SCOPe Domain Sequences for d4ncsa1:

Sequence, based on SEQRES records:

>d4ncsa1 b.68.1.1 (A:4-377) automated matches {Human (Homo sapiens) [TaxId: 9606]}
lpvlqkesvfqsgahayripallylpgqqsllafaeqraskkaehaelivlrrgdydapt
hqvqwqaqevvaqarldghrsmnpcplydaqtgtlflffiaipgqvteqqqlqtranvtr
lcqvtstdhgrtwssprdltdaaigpayrewstfavgpghclqlndrarslvvpayayrk
lhpiqrpipsafcflshdhgrtwarghfvaqdtlecqvaevetgeqrvvtlnarshlrar
vqaqstndgldfqesqlvkklvepppqgcqgsvisfpsprsgpgspaqwllythpthswq
radlgaylnprppapeawsepvllakgscaysdlqsmgtgpdgsplfgclyeandyeeiv
flmftlkqafpaey

Sequence, based on observed residues (ATOM records):

>d4ncsa1 b.68.1.1 (A:4-377) automated matches {Human (Homo sapiens) [TaxId: 9606]}
lpvlqkesvfqsgahayripallylpgqqsllafaeqraaelivlrrgdydapthqvqwq
aqevvaqarldghrsmnpcplydaqtgtlflffiaipganvtrlcqvtstdhgrtwsspr
dltdaaigpayrewstfavgpghclqlndrarslvvpayayrklhpiqrpipsafcflsh
dhgrtwarghfvaqdtlecqvaeveqrvvtlnarshlrarvqaqstndgldfqesqlvkk
lvepppqgcqgsvisfpspraqwllythpthswqradlgaylnprppapeawsepvllak
gscaysdlqsmgtgpdgsplfgclyeandyeeivflmftlkqafpaey

Timeline for d4ncsa1:

• d4ncsa1 first appeared in SCOPe 2.03, called d4ncsa_
  
• d4ncsa1 appears in SCOPe 2.07