SCOPe 2.03: Domain d3wi6d_: 3wi6 D:

Lineage for d3wi6d_ (3wi6 D:)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein MAP kinase activated protein kinase 2, mapkap2 [82789] (1 species)
   CaMK group; MAPKAPK subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [82790] (13 PDB entries)

8. Domain d3wi6d_: 3wi6 D: [229990]
   automated match to d2pzyc_
   complexed with yrz

Details for d3wi6d_

PDB Entry: 3wi6, 2.99 Å

PDB Description: Crystal structure of MAPKAP Kinase-2 (MK2) in complex with non-selective inhibitor

PDB Compounds: (D:) MAP kinase-activated protein kinase 2

SCOPe Domain Sequences for d3wi6d_:

Sequence, based on SEQRES records:

>d3wi6d_ d.144.1.7 (D:) MAP kinase activated protein kinase 2, mapkap2 {Human (Homo sapiens) [TaxId: 9606]}
fhvksglqikknaiiddykvtsqvlglgingkvlqifnkrtqekfalkmlqdcpkarrev
elhwrasqcphivrivdvyenlyagrkcllivmecldggelfsriqdrgdqafterease
imksigeaiqylhsiniahrdvkpenllytskrpnailkltdfgfakettshnslttpcy
tpyyvapevlgpekydkscdmwslgvimyillcgyppfysnhglaispgmktrirmgqye
fpnpewsevseevkmlirnllkteptqrmtitefmnhpwimqstkvpqtplhtsrvlked
ke

Sequence, based on observed residues (ATOM records):

>d3wi6d_ d.144.1.7 (D:) MAP kinase activated protein kinase 2, mapkap2 {Human (Homo sapiens) [TaxId: 9606]}
fhvksglqikknaiiddykvtsqvlglgingkvlqifnkrtqekfalkmlqdcpkarrev
elhwrasqcphivrivdvyenlyagrkcllivmecldggelfsriqdraftereaseimk
sigeaiqylhsiniahrdvkpenllytskrpnailkltdfgfakettspyyvapevlgpe
dkscdmwslgvimyillcgyppfysispgmktrirmgqyefpnpewsevseevkmlirnl
lkteptqrmtitefmnhpwimqstkvpqtplhtsrvlkedke

Timeline for d3wi6d_:

• d3wi6d_ is new in SCOPe 2.03-stable
  
• d3wi6d_ appears in SCOPe 2.04
  
• d3wi6d_ appears in the current release, SCOPe 2.08