SCOPe 2.06: Domain d4m1sa_: 4m1s A:

Lineage for d4m1sa_ (4m1s A:)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
   3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes

4. Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (26 families)
   division into families based on beta-sheet topologies

5. Family c.37.1.8: G proteins [52592] (79 proteins)
   core: mixed beta-sheet of 6 strands, order 231456; strand 2 is antiparallel to the rest

6. Protein automated matches [190047] (29 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [186768] (179 PDB entries)

8. Domain d4m1sa_: 4m1s A: [229893]
   automated match to d4lrwa_
   complexed with 21k, gdp

Details for d4m1sa_

PDB Entry: 4m1s, 1.55 Å

PDB Description: crystal structure of small molecule vinylsulfonamide 13 covalently bound to k-ras g12c

PDB Compounds: (A:) K-Ras GTPase

SCOPe Domain Sequences for d4m1sa_:

Sequence, based on SEQRES records:

>d4m1sa_ c.37.1.8 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
mteyklvvvgacgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetslldildtag
qeeysamrdqymrtgegfllvfainntksfedihhyreqikrvkdsedvpmvlvgnksdl
psrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhk

Sequence, based on observed residues (ATOM records):

>d4m1sa_ c.37.1.8 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
mteyklvvvgacgvgksaltiqliqnhfvdedsyrkqvvidgetslldildtagqeeysa
mrdqymrtgegfllvfainntksfedihhyreqikrvkdsedvpmvlvgnksdlpsrtvd
tkqaqdlarsygipfietsaktrqgvddafytlvreirkhk

Timeline for d4m1sa_:

• d4m1sa_ first appeared in SCOPe 2.03
  
• d4m1sa_ appears in SCOPe 2.05
  
• d4m1sa_ appears in SCOPe 2.07
  
• d4m1sa_ appears in the current release, SCOPe 2.08