SCOPe 2.08: Domain d4cfna1: 4cfn A:1-297

Lineage for d4cfna1 (4cfn A:1-297)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Cyclin-dependent PK, CDK2 [88855] (2 species)
   CMGC group; CDKs subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [88856] (417 PDB entries)
   Uniprot P24941

8. Domain d4cfna1: 4cfn A:1-297 [229801]
   Other proteins in same PDB: d4cfna2, d4cfnb1, d4cfnb2, d4cfnc2, d4cfnd1, d4cfnd2
   automated match to d1oiua_
   complexed with dtt, jym

Details for d4cfna1

PDB Entry: 4cfn, 2.2 Å

PDB Description: Structure-based design of C8-substituted O6-cyclohexylmethoxyguanine CDK1 and 2 inhibitors.

PDB Compounds: (A:) cyclin-dependent kinase 2

SCOPe Domain Sequences for d4cfna1:

Sequence, based on SEQRES records:

>d4cfna1 d.144.1.7 (A:1-297) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
menfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkelnh
pnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchs
hrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyy
stavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsf
pkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlr

Sequence, based on observed residues (ATOM records):

>d4cfna1 d.144.1.7 (A:1-297) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
menfqkvekigegtygvvykarnkltgevvalkkirltegvpstaireisllkelnhpni
vklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchshrv
lhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyysta
vdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsfpkw
arqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlr

Timeline for d4cfna1:

• d4cfna1 first appeared in SCOPe 2.03, called d4cfna_
  
• d4cfna1 appears in SCOPe 2.07