SCOPe 2.03: Domain d4cfnb1: 4cfn B:177-309

Lineage for d4cfnb1 (4cfn B:177-309)

1. Root: SCOPe 2.03

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.74: Cyclin-like [47953] (1 superfamily)
   core: 5 helices; one helix is surrounded by the others

4. Superfamily a.74.1: Cyclin-like [47954] (4 families)
   duplication: consists of two domains of this fold

5. Family a.74.1.1: Cyclin [47955] (9 proteins)

6. Protein Cyclin A [47956] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [47957] (73 PDB entries)
   Uniprot P20248 175-432

8. Domain d4cfnb1: 4cfn B:177-309 [229787]
   Other proteins in same PDB: d4cfna_, d4cfnc_
   automated match to d1h1pb1
   complexed with dtt, jym

Details for d4cfnb1

PDB Entry: 4cfn, 2.2 Å

PDB Description: Structure-based design of C8-substituted O6-cyclohexylmethoxyguanine CDK1 and 2 inhibitors.

PDB Compounds: (B:) Cyclin-A2

SCOPe Domain Sequences for d4cfnb1:

Sequence, based on SEQRES records:

>d4cfnb1 a.74.1.1 (B:177-309) Cyclin A {Human (Homo sapiens) [TaxId: 9606]}
dyhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqnetlhlav
nyidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyitddtytkkqvlrmeh
lvlkvltfdlaap

Sequence, based on observed residues (ATOM records):

>d4cfnb1 a.74.1.1 (B:177-309) Cyclin A {Human (Homo sapiens) [TaxId: 9606]}
dyhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqnetlhlav
nyidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyittytkkqvlrmehlv
lkvltfdlaap

Timeline for d4cfnb1:

• d4cfnb1 is new in SCOPe 2.03-stable
  
• d4cfnb1 appears in SCOPe 2.04
  
• d4cfnb1 appears in the current release, SCOPe 2.08