Lineage for d4mxzb_ (4mxz B:)

  1. Root: SCOPe 2.03
  2. 1396887Class d: Alpha and beta proteins (a+b) [53931] (376 folds)
  3. 1433536Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 1433537Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 1433619Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
    members organized in the groups and subfamiles specified by the comments
  6. 1433768Protein c-src tyrosine kinase [56155] (2 species)
    PTK group; Src subfamily; non-membrane spanning protein tyrosine kinase
  7. 1433769Species Chicken (Gallus gallus) [TaxId:9031] [56157] (37 PDB entries)
  8. 1433838Domain d4mxzb_: 4mxz B: [229460]
    automated match to d3en6b_
    complexed with db8; mutant

Details for d4mxzb_

PDB Entry: 4mxz (more details), 2.58 Å

PDB Description: Src M314L T338M double mutant bound to kinase inhibitor bosutinib
PDB Compounds: (B:) Proto-oncogene tyrosine-protein kinase Src

SCOPe Domain Sequences for d4mxzb_:

Sequence, based on SEQRES records: (download)

>d4mxzb_ d.144.1.7 (B:) c-src tyrosine kinase {Chicken (Gallus gallus) [TaxId: 9031]}
daweipreslrlevklgqgcfgevwmgtwngttrvaiktlkpgtmspeaflqeaqvlkkl
rheklvqlyavvseepiyivmeymskgslldflkgetgkylrlpqlvdmaaqiasgmayv
ermnyvhrdlraanilvgenlvckvadfglarliedneytarqgakfpikwtapeaalyg
rftiksdvwsfgilltelttkgrvpypgmvnrevldqvergyrmpcppecpeslhdlmcq
cwrkepeerptfeylqafledyftstepqyqpgenl

Sequence, based on observed residues (ATOM records): (download)

>d4mxzb_ d.144.1.7 (B:) c-src tyrosine kinase {Chicken (Gallus gallus) [TaxId: 9031]}
daweipreslrlevklgqgcfgevwmgtwngttrvaiktlkpgtmspeaflqeaqvlkkl
rheklvqlyavvseepiyivmeymskgslldflkgetgkylrlpqlvdmaaqiasgmayv
ermnyvhrdlraanilvgenlvckvadfglarlifpikwtapeaalygrftiksdvwsfg
illtelttkgrvpypgmvnrevldqvergyrmpcppecpeslhdlmcqcwrkepeerptf
eylqafledyftstepqyqpgenl

SCOPe Domain Coordinates for d4mxzb_:

Click to download the PDB-style file with coordinates for d4mxzb_.
(The format of our PDB-style files is described here.)

Timeline for d4mxzb_: