Lineage for d4c4ja1 (4c4j A:519-794)

  1. Root: SCOPe 2.06
  2. 2170735Class d: Alpha and beta proteins (a+b) [53931] (385 folds)
  3. 2218047Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 2218048Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 2222093Family d.144.1.0: automated matches [191359] (1 protein)
    not a true family
  6. 2222094Protein automated matches [190417] (25 species)
    not a true protein
  7. 2222237Species Human (Homo sapiens) [TaxId:9606] [187294] (882 PDB entries)
  8. 2223129Domain d4c4ja1: 4c4j A:519-794 [229408]
    Other proteins in same PDB: d4c4ja2
    automated match to d3ceka_
    complexed with x21

Details for d4c4ja1

PDB Entry: 4c4j (more details), 2.5 Å

PDB Description: Structure-based design of orally bioavailable pyrrolopyridine inhibitors of the mitotic kinase MPS1
PDB Compounds: (A:) Dual specificity protein kinase TTK

SCOPe Domain Sequences for d4c4ja1:

Sequence, based on SEQRES records: (download)

>d4c4ja1 d.144.1.0 (A:519-794) automated matches {Human (Homo sapiens) [TaxId: 9606]}
svkgriysilkqigsggsskvfqvlnekkqiyaikyvnleeadnqtldsyrneiaylnkl
qqhsdkiirlydyeitdqyiymvmecgnidlnswlkkkksidpwerksywknmleavhti
hqhgivhsdlkpanflivdgmlklidfgianqmqpdttsvvkdsqvgtvnymppeaikdm
sssrengkskskispksdvwslgcilyymtygktpfqqiinqisklhaiidpnheiefpd
ipekdlqdvlkcclkrdpkqrisipellahpyvqiq

Sequence, based on observed residues (ATOM records): (download)

>d4c4ja1 d.144.1.0 (A:519-794) automated matches {Human (Homo sapiens) [TaxId: 9606]}
svkgriysilkqigsggsskvfqvlnekkqiyaikyvnleeadnqtldsyrneiaylnkl
qqhsdkiirlydyeitdqyiymvmecgnidlnswlkkkksidpwerksywknmleavhti
hqhgivhsdlkpanflivdgmlklidfgianqmqpdtvgtvnymppeaikdmsskispks
dvwslgcilyymtygktpfqqiinqisklhaiidpnheiefpdipekdlqdvlkcclkrd
pkqrisipellahpyvqiq

SCOPe Domain Coordinates for d4c4ja1:

Click to download the PDB-style file with coordinates for d4c4ja1.
(The format of our PDB-style files is described here.)

Timeline for d4c4ja1:

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Domains from same chain:
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d4c4ja2