SCOPe 2.08: Domain d3zbxa_: 3zbx A:

Lineage for d3zbxa_ (3zbx A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (20 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (850 PDB entries)

8. Domain d3zbxa_: 3zbx A: [229380]
   automated match to d4ap7a_
   complexed with 6xe

Details for d3zbxa_

PDB Entry: 3zbx, 2.2 Å

PDB Description: x-ray structure of c-met kinase in complex with inhibitor 6-((6-(4- fluorophenyl)-(1,2,4)triazolo(4,3-b)(1,2,4)triazin-3-yl)methyl) quinoline.

PDB Compounds: (A:) Hepatocyte growth factor receptor

SCOPe Domain Sequences for d3zbxa_:

Sequence, based on SEQRES records:

>d3zbxa_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
npelvqavqhvvigpsslivhfnevigrghfgcvyhgtlldndgkkihcavkslnritdi
gevsqfltegiimkdfshpnvlsllgiclrsegsplvvlpymkhgdlrnfirnethnptv
kdligfglqvakgmkylaskkfvhrdlaarncmldekftvkvadfglardmydkeyysvh
nktgaklpvkwmaleslqtqkfttksdvwsfgvllwelmtrgappypdvntfditvyllq
grrllqpeycpdplyevmlkcwhpkaemrpsfselvsrisaifstfi

Sequence, based on observed residues (ATOM records):

>d3zbxa_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
npelvqavqhvvigpsslivhfnevigrghfgcvyhgtllkkihcavkslnritdigevs
qfltegiimkdfshpnvlsllgiclrsegsplvvlpymkhgdlrnfirnethnptvkdli
gfglqvakgmkylaskkfvhrdlaarncmldekftvkvadfglardmydkeyysvhnktg
aklpvkwmaleslqtqkfttksdvwsfgvllwelmtrgappypdvntfditvyllqgrrl
lqpeycpdplyevmlkcwhpkaemrpsfselvsrisaifstfi

Timeline for d3zbxa_:

• d3zbxa_ first appeared in SCOPe 2.03
  
• d3zbxa_ appears in SCOPe 2.07