SCOPe 2.05: Domain d4i0sa_: 4i0s A:

Lineage for d4i0sa_ (4i0s A:)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Tyrosine-protein kinase SYK [118131] (1 species)
   PTK group; SYK/ZAP-70 subfamily; non-membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [118132] (52 PDB entries)
   Uniprot P43405 363-635 # structure of the SH2 domain tandem region (9-265) is also known (55576)

8. Domain d4i0sa_: 4i0s A: [228656]
   automated match to d1xbba_
   complexed with 1b5

Details for d4i0sa_

PDB Entry: 4i0s, 1.98 Å

PDB Description: crystal structure of spleen tyrosine kinase complexed with 2-(6- chloro-1-methyl-1h-indazol-3-yl)-5h-pyrrolo[2,3-b]pyrazine-7- carboxylic acid isopropylamide

PDB Compounds: (A:) Tyrosine-protein kinase SYK

SCOPe Domain Sequences for d4i0sa_:

Sequence, based on SEQRES records:

>d4i0sa_ d.144.1.7 (A:) Tyrosine-protein kinase SYK {Human (Homo sapiens) [TaxId: 9606]}
vyldrklltledkelgsgnfgtvkkgyyqmkkvvktvavkilkneandpalkdellaean
vmqqldnpyivrmigiceaeswmlvmemaelgplnkylqqnrhvkdkniielvhqvsmgm
kyleesnfvhrdlaarnvllvtqhyakisdfglskalradenyykaqthgkwpvkwyape
cinyykfssksdvwsfgvlmweafsygqkpyrgmkgsevtamlekgermgcpagcpremy
dlmnlcwtydvenrpgfaavelrlrnyyydvvneghh

Sequence, based on observed residues (ATOM records):

>d4i0sa_ d.144.1.7 (A:) Tyrosine-protein kinase SYK {Human (Homo sapiens) [TaxId: 9606]}
vyldrklltledkelgsgnfgtvkkgyyqmkkvvktvavkilpalkdellaeanvmqqld
npyivrmigiceaeswmlvmemaelgplnkylqqnrhvkdkniielvhqvsmgmkylees
nfvhrdlaarnvllvtqhyakisdfglskalradenyykakwpvkwyapecinyykfssk
sdvwsfgvlmweafsygqkpyrgmkgsevtamlekgermgcpagcpremydlmnlcwtyd
venrpgfaavelrlrnyyydvvneghh

Timeline for d4i0sa_:

• d4i0sa_ first appeared in SCOPe 2.03
  
• d4i0sa_ appears in SCOPe 2.04
  
• d4i0sa_ is called d4i0sa1 in SCOPe 2.06
  
• d4i0sa_ appears in the current release, SCOPe 2.08, called d4i0sa1