SCOPe 2.08: Domain d4c3fa_: 4c3f A:

Lineage for d4c3fa_ (4c3f A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Lymphocyte kinase (lck) [56153] (1 species)
   PTK group; Src subfamily; non-membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [56154] (35 PDB entries)

8. Domain d4c3fa_: 4c3f A: [228453]
   automated match to d3mpma_
   complexed with 7kw

Details for d4c3fa_

PDB Entry: 4c3f, 1.72 Å

PDB Description: structure of lck in complex with a compound discovered by virtual fragment linking

PDB Compounds: (A:) Tyrosine-protein kinase Lck

SCOPe Domain Sequences for d4c3fa_:

Sequence, based on SEQRES records:

>d4c3fa_ d.144.1.7 (A:) Lymphocyte kinase (lck) {Human (Homo sapiens) [TaxId: 9606]}
wevpretlklverlgagqfgevwmgyynghtkvavkslkqgsmspdaflaeanlmkqlqh
qrlvrlyavvtqepiyiiteymengslvdflktpsgikltinklldmaaqiaegmafiee
rnyihrnlraanilvsdtlsckiadfglarliedneytaregakfpikwtapeainygtf
tiksdvwsfgillteivthgripypgmtnpeviqnlergyrmvrpdncpeelyqlmrlcw
kerpedrptfdylrsvledff

Sequence, based on observed residues (ATOM records):

>d4c3fa_ d.144.1.7 (A:) Lymphocyte kinase (lck) {Human (Homo sapiens) [TaxId: 9606]}
wevpretlklverlgagqfgevwmgyynghtkvavkslkqgsmspdaflaeanlmkqlqh
qrlvrlyavvtqepiyiiteymengslvdflktpsgikltinklldmaaqiaegmafiee
rnyihrnlraanilvsdtlsckiadfglarliedneytarfpikwtapeainygtftiks
dvwsfgillteivthgripypgmtnpeviqnlergyrmvrpdncpeelyqlmrlcwkerp
edrptfdylrsvledff

Timeline for d4c3fa_:

• d4c3fa_ first appeared in SCOPe 2.03
  
• d4c3fa_ appears in SCOPe 2.07