SCOPe 2.04: Domain d4jyuh_: 4jyu H:

Lineage for d4jyuh_ (4jyu H:)

1. Root: SCOPe 2.04

2. Class b: All beta proteins [48724] (176 folds)

3. Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
   barrel, closed; n=6, S=8; greek-key
   duplication: consists of two domains of the same fold

4. Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families)

5. Family b.47.1.2: Eukaryotic proteases [50514] (48 proteins)

6. Protein Coagulation factor VIIa [50550] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50551] (39 PDB entries)
   Uniprot P08709 213-466 ! Uniprot P08709 213-446

8. Domain d4jyuh_: 4jyu H: [227558]
   Other proteins in same PDB: d4jyul_
   automated match to d1klih_
   complexed with 1ok, ca, gol, so4

Details for d4jyuh_

PDB Entry: 4jyu, 1.8 Å

PDB Description: structure of factor viia in complex with the inhibitor (2r)-2-[(1-aminoisoquinolin-6-yl)amino]-2-[3-ethoxy-4-(propan-2-yloxy)phenyl]-n-(phenylsulfonyl)ethanamide

PDB Compounds: (H:) Factor VII light chain

SCOPe Domain Sequences for d4jyuh_:

Sequence; same for both SEQRES and ATOM records:

>d4jyuh_ b.47.1.2 (H:) Coagulation factor VIIa {Human (Homo sapiens) [TaxId: 9606]}
ivggkvcpkgecpwqvlllvngaqlcggtlintiwvvsaahcfdkiknwrnliavlgehd
lsehdgdeqsrrvaqviipstyvpgttnhdiallrlhqpvvltdhvvplclpertfsert
lafvrfslvsgwgqlldrgatalelmvlnvprlmtqdclqqsrkvgdspniteymfcagy
sdgskdsckgdsggphathyrgtwyltgivswgqgcatvghfgvytrvsqyiewlqklmr
seprpgvllrapfp

Timeline for d4jyuh_:

• d4jyuh_ first appeared in SCOPe 2.03
  
• d4jyuh_ appears in SCOPe 2.05
  
• d4jyuh_ appears in the current release, SCOPe 2.08