SCOPe 2.05: Domain d4hxra_: 4hxr A:

Lineage for d4hxra_ (4hxr A:)

1. Root: SCOPe 2.05

2. Class a: All alpha proteins [46456] (286 folds)

3. Fold a.29: Bromodomain-like [47363] (15 superfamilies)
   4 helices; bundle; minor mirror variant of up-and-down topology

4. Superfamily a.29.2: Bromodomain [47370] (2 families)

5. Family a.29.2.0: automated matches [191428] (1 protein)
   not a true family

6. Protein automated matches [190615] (7 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187641] (258 PDB entries)

8. Domain d4hxra_: 4hxr A: [222781]
   automated match to d2nxba_
   complexed with 1a4

Details for d4hxra_

PDB Entry: 4hxr, 1.53 Å

PDB Description: brd4 bromodomain 1 complex with n-[3-(2-oxo-2,3-dihydro-1,3-thiazol-4-yl)phenyl]thiophene-2-sulfonamide inhibitor

PDB Compounds: (A:) Bromodomain-containing protein 4

SCOPe Domain Sequences for d4hxra_:

Sequence; same for both SEQRES and ATOM records:

>d4hxra_ a.29.2.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
mnppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykiik
tpmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqkin
elpte

Timeline for d4hxra_:

• d4hxra_ first appeared in SCOPe 2.03
  
• d4hxra_ appears in SCOPe 2.04
  
• d4hxra_ is called d4hxra1 in SCOPe 2.06
  
• d4hxra_ appears in the current release, SCOPe 2.08, called d4hxra1