SCOPe 2.05: Domain d4hgwb1: 4hgw B:1-112

Lineage for d4hgwb1 (4hgw B:1-112)

1. Root: SCOPe 2.05

2. Class b: All beta proteins [48724] (176 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (31 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (33 proteins)

6. Protein Immunoglobulin heavy chain variable domain, VH [88543] (21 species)
   VH domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VH domains with artificial or grafted exogenous CDRs are listed as engineered species

7. Species Mouse (Mus musculus), cluster 1 [TaxId:10090] [88548] (63 PDB entries)
   Uniprot P01796 # ! HV27_MOUSE Ig heavy chain V-III region A4

8. Domain d4hgwb1: 4hgw B:1-112 [222600]
   Other proteins in same PDB: d4hgwa1, d4hgwa2, d4hgwb2
   automated match to d3t65b1
   complexed with zn

Details for d4hgwb1

PDB Entry: 4hgw, 1.65 Å

PDB Description: crystal structure of s25-2 in complex with a 5,6-dehydro-kdo disaccharide

PDB Compounds: (B:) antibody fab fragment, heavy chain

SCOPe Domain Sequences for d4hgwb1:

Sequence, based on SEQRES records:

>d4hgwb1 b.1.1.1 (B:1-112) Immunoglobulin heavy chain variable domain, VH {Mouse (Mus musculus), cluster 1 [TaxId: 10090]}
evklvesggglvqsggslrlscatsgftftdyymswvrqppgkalewlgfirnkangytt
eyspsvkgrftisrdnsqsilylqmntlraedsatyycardhdgyyerfsywgqgtlvtv
sa

Sequence, based on observed residues (ATOM records):

>d4hgwb1 b.1.1.1 (B:1-112) Immunoglobulin heavy chain variable domain, VH {Mouse (Mus musculus), cluster 1 [TaxId: 10090]}
evklvesggglvqsggslrlscatsgftftdyymswvrqppgkalewlgfirnkangytt
eyspsvkgrftisrdnsqsilylqmntlraedsatyycardhdgyyerfswgqgtlvtvs
a

Timeline for d4hgwb1:

• d4hgwb1 first appeared in SCOPe 2.03
  
• d4hgwb1 appears in SCOPe 2.04
  
• d4hgwb1 appears in SCOPe 2.06
  
• d4hgwb1 appears in the current release, SCOPe 2.08