SCOPe 2.03: Domain d4fkoa_: 4fko A:

Lineage for d4fkoa_ (4fko A:)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Cyclin-dependent PK, CDK2 [88855] (2 species)
   CMGC group; CDKs subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [88856] (335 PDB entries)
   Uniprot P24941

8. Domain d4fkoa_: 4fko A: [221252]
   automated match to d1gz8a_
   complexed with 20k, act

Details for d4fkoa_

PDB Entry: 4fko, 1.55 Å

PDB Description: Crystal structure of the cdk2 in complex with thiazolylpyrimidine inhibitor

PDB Compounds: (A:) cyclin-dependent kinase 2

SCOPe Domain Sequences for d4fkoa_:

Sequence, based on SEQRES records:

>d4fkoa_ d.144.1.7 (A:) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
menfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkelnh
pnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchs
hrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyy
stavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsf
pkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl

Sequence, based on observed residues (ATOM records):

>d4fkoa_ d.144.1.7 (A:) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
menfqkvekigegtygvvykarnkltgevvalkkirlpstaireisllkelnhpnivkll
dvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchshrvlhrd
lkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyystavdiw
slgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsfpkwarqd
fskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl

Timeline for d4fkoa_:

• d4fkoa_ is new in SCOPe 2.03-stable
  
• d4fkoa_ appears in SCOPe 2.04
  
• d4fkoa_ appears in the current release, SCOPe 2.08