SCOPe 2.03: Domain d4epya_: 4epy A:

Lineage for d4epya_ (4epy A:)

1. Root: SCOPe 2.03

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
   3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes

4. Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (25 families)
   division into families based on beta-sheet topologies

5. Family c.37.1.8: G proteins [52592] (79 proteins)
   core: mixed beta-sheet of 6 strands, order 231456; strand 2 is antiparallel to the rest

6. Protein automated matches [190047] (16 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [186768] (113 PDB entries)

8. Domain d4epya_: 4epy A: [220770]
   automated match to d4epxa_
   complexed with 0qy, gdp, mg

Details for d4epya_

PDB Entry: 4epy, 1.8 Å

PDB Description: Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-mediated Activation

PDB Compounds: (A:) GTPase KRas

SCOPe Domain Sequences for d4epya_:

Sequence; same for both SEQRES and ATOM records:

>d4epya_ c.37.1.8 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
gmteyklvvvgavgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildta
gqeeysamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnksd
lpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhkek

Timeline for d4epya_:

• d4epya_ is new in SCOPe 2.03-stable
  
• d4epya_ appears in SCOPe 2.04
  
• d4epya_ appears in the current release, SCOPe 2.08, called d4epya1