SCOPe 2.06: Domain d4e4lb_: 4e4l B:

Lineage for d4e4lb_ (4e4l B:)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (25 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (882 PDB entries)

8. Domain d4e4lb_: 4e4l B: [220301]
   automated match to d3bhhd_
   complexed with 0nh

Details for d4e4lb_

PDB Entry: 4e4l, 2 Å

PDB Description: JAK1 kinase (JH1 domain) in complex with compound 30

PDB Compounds: (B:) Tyrosine-protein kinase JAK1

SCOPe Domain Sequences for d4e4lb_:

Sequence, based on SEQRES records:

>d4e4lb_ d.144.1.0 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
evdpthfekrflkrirdlgeghfgkvelcrydpegdntgeqvavkslkpesggnhiadlk
keieilrnlyhenivkykgictedggngiklimeflpsgslkeylpknknkinlkqqlky
avqickgmdylgsrqyvhrdlaarnvlvesehqvkigdfgltkaietdkeyytvkddrds
pvfwyapeclmqskfyiasdvwsfgvtlhelltycdsdsspmalflkmigpthgqmtvtr
lvntlkegkrlpcppncpdevyqlmrkcwefqpsnrtsfqnliegfeallk

Sequence, based on observed residues (ATOM records):

>d4e4lb_ d.144.1.0 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
evdpthfekrflkrirdlgeghfgkvelcrydpegdntgeqvavkslknhiadlkkeiei
lrnlyhenivkykgictgiklimeflpsgslkeylpknknkinlkqqlkyavqickgmdy
lgsrqyvhrdlaarnvlvesehqvkigdfgltkaietdkeyytvkddrdspvfwyapecl
mqskfyiasdvwsfgvtlhelltycdsdsspmalflkmigpthgqmtvtrlvntlkegkr
lpcppncpdevyqlmrkcwefqpsnrtsfqnliegfeallk

Timeline for d4e4lb_:

• d4e4lb_ first appeared in SCOPe 2.03
  
• d4e4lb_ appears in SCOPe 2.05
  
• d4e4lb_ appears in SCOPe 2.07
  
• d4e4lb_ appears in the current release, SCOPe 2.08