SCOPe 2.08: Domain d4auaa_: 4aua A:

Lineage for d4auaa_ (4aua A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Cyclin-dependent PK, CDK6 [88859] (1 species)
   CMGC group; CDKs subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [88860] (16 PDB entries)

8. Domain d4auaa_: 4aua A: [219151]
   automated match to d3nuxa_
   complexed with 4au

Details for d4auaa_

PDB Entry: 4aua, 2.31 Å

PDB Description: liganded x-ray crystal structure of cyclin dependent kinase 6 (cdk6)

PDB Compounds: (A:) cyclin-dependent kinase 6

SCOPe Domain Sequences for d4auaa_:

Sequence, based on SEQRES records:

>d4auaa_ d.144.1.7 (A:) Cyclin-dependent PK, CDK6 {Human (Homo sapiens) [TaxId: 9606]}
qqyecvaeigegaygkvfkardlknggrfvalkrvrvqtgeegmplstirevavlrhlet
fehpnvvrlfdvctvsrtdretkltlvfehvdqdlttyldkvpepgvptetikdmmfqll
rgldflhshrvvhrdlkpqnilvtssgqikladfglariysfqmaltsvvvtlwyrapev
llqssyatpvdlwsvgcifaemfrrkplfrgssdvdqlgkildviglpgeedwprdvalp
rqafhsksaqpiekfvtdidelgkdlllkcltfnpakrisaysalshpyfq

Sequence, based on observed residues (ATOM records):

>d4auaa_ d.144.1.7 (A:) Cyclin-dependent PK, CDK6 {Human (Homo sapiens) [TaxId: 9606]}
qqyecvaeigegagkvfkardlknggrfvalkrstirevavlrhletfehpnvvrlfdvc
tkltlvfehvdqdlttyldkvpepgvptetikdmmfqllrgldflhshrvvhrdlkpqni
lvtssgqikladfglatlwyrapevllqssyatpvdlwsvgcifaemfrrkplfrgssdv
dqlgkildviglpgeedwprdvalprqafhsksaqpiekfvtdidelgkdlllkcltfnp
akrisaysalshpyfq

Timeline for d4auaa_:

• d4auaa_ first appeared in SCOPe 2.03
  
• d4auaa_ appears in SCOPe 2.07