SCOPe 2.03: Domain d3zxre2: 3zxr E:105-478

Lineage for d3zxre2 (3zxr E:105-478)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.128: Glutamine synthetase/guanido kinase [55930] (1 superfamily)
   duplication: common core consists of two beta-alpha-beta2-alpha repeats

4. Superfamily d.128.1: Glutamine synthetase/guanido kinase [55931] (6 families)

5. Family d.128.1.0: automated matches [227250] (1 protein)
   not a true family

6. Protein automated matches [227028] (5 species)
   not a true protein

7. Species Mycobacterium tuberculosis [TaxId:83332] [226759] (6 PDB entries)

8. Domain d3zxre2: 3zxr E:105-478 [218567]
   Other proteins in same PDB: d3zxra1, d3zxrb1, d3zxrc1, d3zxrd1, d3zxre1, d3zxrf1
   automated match to d1f52a2
   complexed with cl, iq1, mg, p3s, po4

Details for d3zxre2

PDB Entry: 3zxr, 2.15 Å

PDB Description: crystal structure of mycobacterium tuberculosis glutamine synthetase in complex with tri-substituted imidazole inhibitor (3-(2-tert-butyl- 5-(pyridin-4-yl)-1h-imidazol-4-yl)quinoline) and l-methionine-s- sulfoximine phosphate.

PDB Compounds: (E:) glutamine synthetase 1

SCOPe Domain Sequences for d3zxre2:

Sequence; same for both SEQRES and ATOM records:

>d3zxre2 d.128.1.0 (E:105-478) automated matches {Mycobacterium tuberculosis [TaxId: 83332]}
srdprniarkaenylistgiadtayfgaeaefyifdsvsfdsrangsfyevdaisgwwnt
gaateadgspnrgykvrhkggyfpvapndqyvdlrdkmltnlinsgfilekghhevgsgg
qaeinyqfnsllhaaddmqlykyiikntawqngktvtfmpkplfgdngsgmhchqslwkd
gaplmydetgyaglsdtarhyiggllhhapsllaftnptvnsykrlvpgyeapinlvysq
rnrsacvripitgsnpkakrlefrspdssgnpylafsamlmagldgiknkiepqapvdkd
lyelppeeaasipqtptqlsdvidrleadheylteggvftndlietwisfkreneiepvn
irphpyefalyydv

Timeline for d3zxre2:

• d3zxre2 is new in SCOPe 2.03-stable
  
• d3zxre2 appears in SCOPe 2.04
  
• d3zxre2 appears in the current release, SCOPe 2.08